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Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease : A Randomized Controlled Trial-The OmegAD Study
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- Tofiq, avin, 1996- (author)
- School of Medicine, Örebro University, Örebro, Sweden,Örebro Univ, Sch Med, Örebro, Sweden.
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- Zetterberg, Henrik (author)
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL, London, United Kingdom; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom,Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Mölndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Mölndal, Sweden.;UCL, UK Dementia Res Inst, London, England.;UCL Inst Neurol, Dept Neurodegenerat Dis, London, England.
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- Blennow, Kaj (author)
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden,Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Mölndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Mölndal, Sweden.
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- Basun, Hans (author)
- BioArctic AB, Stockholm, Sweden; Spinemedical AB, Stockholm, Sweden; Uppsala University Hospital, Uppsala, Sweden,BioArctic AB, Stockholm, Sweden.;Spinemed AB, Stockholm, Sweden.;Uppsala Univ Hosp, Uppsala, Sweden.
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- Cederholm, Tommy (author)
- Uppsala universitet,Klinisk nutrition och metabolism,Karolinska Univ Hosp, Theme Ageing, Stockholm, Sweden.
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- Eriksdotter, Maria (author)
- Karolinska Institutet,Karolinska Univ Hosp, Theme Ageing, Stockholm, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.
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- Faxén-Irving, Gerd (author)
- Karolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.
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- Hjorth, Erik (author)
- Karolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.
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- Jernerén, Fredrik (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Schultzberg, Marianne (author)
- Karolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.
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- Wahlund, Lars-Olof (author)
- Karolinska Institutet,Karolinska Univ Hosp, Theme Ageing, Stockholm, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.
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- Palmblad, Jan (author)
- Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp Huddinge, Dept Med, Stockholm, Sweden.
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- Freund-Levi, Yvonne, 1956- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden; Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University Hospital Örebro, Örebro, Sweden; Department of Old Age Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom,Örebro Univ, Sch Med, Örebro, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Div Clin Geriatr, Stockholm, Sweden.;Univ Hosp Örebro, Dept Psychiat, Örebro, Sweden.;Kings Coll London, Dept Old Age Psychiat Psychol & Neurosci, London, England.
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School of Medicine, Örebro University, Örebro, Sweden Örebro Univ, Sch Med, Örebro, Sweden (creator_code:org_t)
- IOS Press, 2021
- English.
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In: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 83:3, s. 1291-1301
- Related links:
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Abstract
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- BACKGROUND: Studies have suggested a connection between a decrease in the levels of polyunsaturated fatty acids (PUFAs) and Alzheimer's disease (AD). We aimed to assess the effect of supplementation with omega-3 fatty acids (n-3 FAs) on biomarkers analyzed in the cerebrospinal fluid (CSF) of patients diagnosed with AD.OBJECTIVE: To investigate the effects of daily supplementation with 2.3 g of PUFAs in AD patients on the biomarkers in CSF described below. We also explored the possible correlation between these biomarkers and the performance in the cognitive test Mini-Mental State Examination (MMSE).METHODS: Thirty-three patients diagnosed with AD were randomized to either treatment with a daily intake of 2.3 g of n-3 FAs (n = 18) or placebo (n = 15). CSF samples were collected at baseline and after six months of treatment, and the following biomarkers were analyzed: Aβ 38, Aβ 40, Aβ 42, t-tau, p-tau, neurofilament light (NfL), chitinase-3-like protein 1 (YKL-40), acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), soluble IL-1 receptor type II (sIL-1RII), and IL-6.RESULTS: There were no significant differences between the groups concerning the level of the different biomarkers in the CSF at baseline. Within the treatment group, there was a small but significant increase in both YKL-40 (p = 0.04) and NfL (p = 0.03), while the other CSF biomarkers remained stable.CONCLUSION: Supplementation with n-3 FAs had a statistically significant effect on NfL and YKL-40, resulting in an increase of both biomarkers, indicating a possible increase of inflammatory response and axonal damage. This increase in biomarkers did not correlate with MMSE score.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Dementia
- Chitinase-3-like protein 1
- YKL-40
- inflammation
- mini-mental state examination
- neurodegeneration
- neurofilament light
Publication and Content Type
- ref (subject category)
- art (subject category)
To the university's database
- By the author/editor
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Tofiq, avin, 199 ...
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Zetterberg, Henr ...
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Blennow, Kaj
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Basun, Hans
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Cederholm, Tommy
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Eriksdotter, Mar ...
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show more...
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Faxén-Irving, Ge ...
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Hjorth, Erik
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Jernerén, Fredri ...
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Schultzberg, Mar ...
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Wahlund, Lars-Ol ...
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Palmblad, Jan
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Freund-Levi, Yvo ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Alzhe ...
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Örebro University
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Karolinska Institutet
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Uppsala University