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Effects of Peroral ...
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Tofiq, avin,1996-School of Medicine, Örebro University, Örebro, Sweden,Örebro Univ, Sch Med, Örebro, Sweden.
(author)
Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease : A Randomized Controlled Trial-The OmegAD Study
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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IOS Press,2021
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:oru-93857
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93857URI
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https://doi.org/10.3233/JAD-210007DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147806770URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457931URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding agencies:Pronova Biocare A/SFunds of CapioOdd FellowSwedish Society of PhysiciansLion's SwedenStohne's FoundationAlzheimer Drug Discovery Foundation (ADDF), USA RDAPB-201 809-2016615 2018092016862ALF ALFGBG-715986European Union Joint Program for Neurodegenerative Disorders JPND2019466-236European Research Council (ERC) 681712 Swedish State Support for Clinical Research ALFGBG-720931UK Dementia Research Institute at UCLSarfond 31 Forskning Senil demensRegion Auvergne-Rhone-AlpesRegion Bourgogne-Franche-ComteRegion Hauts-de-FranceRegion Nouvelle-Aquitaine
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BACKGROUND: Studies have suggested a connection between a decrease in the levels of polyunsaturated fatty acids (PUFAs) and Alzheimer's disease (AD). We aimed to assess the effect of supplementation with omega-3 fatty acids (n-3 FAs) on biomarkers analyzed in the cerebrospinal fluid (CSF) of patients diagnosed with AD.OBJECTIVE: To investigate the effects of daily supplementation with 2.3 g of PUFAs in AD patients on the biomarkers in CSF described below. We also explored the possible correlation between these biomarkers and the performance in the cognitive test Mini-Mental State Examination (MMSE).METHODS: Thirty-three patients diagnosed with AD were randomized to either treatment with a daily intake of 2.3 g of n-3 FAs (n = 18) or placebo (n = 15). CSF samples were collected at baseline and after six months of treatment, and the following biomarkers were analyzed: Aβ 38, Aβ 40, Aβ 42, t-tau, p-tau, neurofilament light (NfL), chitinase-3-like protein 1 (YKL-40), acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), soluble IL-1 receptor type II (sIL-1RII), and IL-6.RESULTS: There were no significant differences between the groups concerning the level of the different biomarkers in the CSF at baseline. Within the treatment group, there was a small but significant increase in both YKL-40 (p = 0.04) and NfL (p = 0.03), while the other CSF biomarkers remained stable.CONCLUSION: Supplementation with n-3 FAs had a statistically significant effect on NfL and YKL-40, resulting in an increase of both biomarkers, indicating a possible increase of inflammatory response and axonal damage. This increase in biomarkers did not correlate with MMSE score.
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Zetterberg, HenrikDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL, London, United Kingdom; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom,Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Mölndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Mölndal, Sweden.;UCL, UK Dementia Res Inst, London, England.;UCL Inst Neurol, Dept Neurodegenerat Dis, London, England.
(author)
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Blennow, KajDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden,Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Mölndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Mölndal, Sweden.
(author)
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Basun, HansBioArctic AB, Stockholm, Sweden; Spinemedical AB, Stockholm, Sweden; Uppsala University Hospital, Uppsala, Sweden,BioArctic AB, Stockholm, Sweden.;Spinemed AB, Stockholm, Sweden.;Uppsala Univ Hosp, Uppsala, Sweden.
(author)
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Cederholm, TommyUppsala universitet,Klinisk nutrition och metabolism,Karolinska Univ Hosp, Theme Ageing, Stockholm, Sweden.(Swepub:uu)tomce419
(author)
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Eriksdotter, MariaKarolinska Institutet,Karolinska Univ Hosp, Theme Ageing, Stockholm, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.
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Faxén-Irving, GerdKarolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.
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Hjorth, ErikKarolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.
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Jernerén, FredrikUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)frjer991
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Schultzberg, MarianneKarolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.
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Wahlund, Lars-OlofKarolinska Institutet,Karolinska Univ Hosp, Theme Ageing, Stockholm, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.
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Palmblad, JanKarolinska Institutet,Karolinska Inst, Karolinska Univ Hosp Huddinge, Dept Med, Stockholm, Sweden.
(author)
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Freund-Levi, Yvonne,1956-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden; Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University Hospital Örebro, Örebro, Sweden; Department of Old Age Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom,Örebro Univ, Sch Med, Örebro, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Div Clin Geriatr, Stockholm, Sweden.;Univ Hosp Örebro, Dept Psychiat, Örebro, Sweden.;Kings Coll London, Dept Old Age Psychiat Psychol & Neurosci, London, England.(Swepub:oru)yfi
(author)
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School of Medicine, Örebro University, Örebro, SwedenÖrebro Univ, Sch Med, Örebro, Sweden.
(creator_code:org_t)
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In:Journal of Alzheimer's Disease: IOS Press83:3, s. 1291-13011387-28771875-8908
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