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Risk of pre-eclamps...
Risk of pre-eclampsia after gastric bypass : a matched cohort study
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- Johansson, Kari (author)
- Karolinska Institutet
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- Wikström, Anna-Karin, 1965- (author)
- Uppsala universitet,Klinisk obstetrik,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.
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- Söderling, Jonas (author)
- Karolinska Institutet
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- Näslund, Ingmar (author)
- Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro,Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden.
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- Ottosson, Johan, 1957- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery,Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden.
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- Neovius, Martin (author)
- Karolinska Institutet
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- Stephansson, Olof (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-09-07
- 2022
- English.
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In: British Journal of Obstetrics and Gynecology. - : Blackwell Publishing. - 1470-0328 .- 1471-0528. ; 129:3, s. 461-471
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Abstract
Subject headings
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- OBJECTIVE: To investigate whether gastric bypass before pregnancy is associated with reduced risk of preeclampsia.DESIGN: Nationwide matched cohort study.SETTING: Swedish national health care.POPULATION: =2766:2766) on pre-surgery/early-pregnancy BMI, diabetes status (pre-surgery/pre-conception), maternal age, early-pregnancy smoking status, educational level, height, country of birth, delivery year and history of preeclampsia.MAIN OUTCOME MEASURES: Preeclampsia categorised into any, preterm onset (<37+0 weeks), and term onset (≥37+0 weeks).RESULTS: (39kg). Post-gastric bypass pregnancies had lower risk of preeclampsia compared to pre-surgery BMI-matched controls (1.7 vs. 9.7 per 100 pregnancies; hazard ratio [HR] 0.21, 95%CI 0.15-0.28) and early-pregnancy BMI-matched controls (1.9 vs. 5.0 per 100 pregnancies; HR 0.44, 95%CI 0.33-0.60). Although relative risks for preeclampsia for post-gastric bypass pregnancies vs. pre-surgery matched controls was similar, absolute risk differences were significantly greater for nulliparous (RD -13.6 per 100 pregnancies, 95%CI -16.1 to -11.2) vs. parous women (RD -4.4 per 100 pregnancies, 95%CI -5.7 to -3.1).CONCLUSION: We found that gastric bypass was associated with lower risk of preeclampsia, with the largest absolute risk reduction among nulliparous women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Bariatric surgery
- eclampsia
- gestational hypertension
- hypertension
- obesity
- overweight
- weight loss
- weight-loss surgery
Publication and Content Type
- ref (subject category)
- art (subject category)
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