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Metabolomics and li...
Metabolomics and lipidomics in NAFLD : biomarkers and non-invasive diagnostic tests
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- Masoodi, Mojgan (author)
- Institute of Clinical Chemistry, Bern University Hospital, Bern, Switzerland
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- Gastaldelli, Amalia (author)
- Institute of Clinical Physiology, CNR, Pisa, Italy
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- Hyötyläinen, Tuulia, 1971- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Arretxe, Enara (author)
- OWL Metabolomics, Bizkaia Technology Park, Derio, Spain
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- Alonso, Cristina (author)
- OWL Metabolomics, Bizkaia Technology Park, Derio, Spain
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- Gaggini, Melania (author)
- Institute of Clinical Physiology, CNR, Pisa, Italy
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- Brosnan, Julia (author)
- Pfizer Inc., Cambridge, MA, USA
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- Anstee, Quentin M. (author)
- Clinical & Translational Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
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- Millet, Oscar (author)
- Precision Medicine & Metabolism, CIC bioGUNE, CIBERehd, BRTA, Bizkaia Technology Park, Derio, Spain
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- Ortiz, Pablo (author)
- OWL Metabolomics, Bizkaia Technology Park, Derio, Spain
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- Mato, Jose M. (author)
- Precision Medicine & Metabolism, CIC bioGUNE, CIBERehd, BRTA, Bizkaia Technology Park, Derio, Spain
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- Dufour, Jean-Francois (author)
- University Clinic of Visceral Surgery and Medicine, Inselspital Bern, Bern, Switzerland; Hepatology, Department of BioMedical Research, University of Bern, Bern, Switzerland
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- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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(creator_code:org_t)
- 2021-09-10
- 2021
- English.
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In: Nature Reviews. Gastroenterology & Hepatology. - : Nature Publishing Group. - 1759-5045 .- 1759-5053. ; 18:12, s. 835-856
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide and is often associated with aspects of metabolic syndrome. Despite its prevalence and the importance of early diagnosis, there is a lack of robustly validated biomarkers for diagnosis, prognosis and monitoring of disease progression in response to a given treatment. In this Review, we provide an overview of the contribution of metabolomics and lipidomics in clinical studies to identify biomarkers associated with NAFLD and nonalcoholic steatohepatitis (NASH). In addition, we highlight the key metabolic pathways in NAFLD and NASH that have been identified by metabolomics and lipidomics approaches and could potentially be used as biomarkers for non-invasive diagnostic tests. Overall, the studies demonstrated alterations in amino acid metabolism and several aspects of lipid metabolism including circulating fatty acids, triglycerides, phospholipids and bile acids. Although we report several studies that identified potential biomarkers, few have been validated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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- By the author/editor
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Masoodi, Mojgan
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Gastaldelli, Ama ...
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Hyötyläinen, Tuu ...
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Arretxe, Enara
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Alonso, Cristina
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Gaggini, Melania
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Brosnan, Julia
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Anstee, Quentin ...
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Millet, Oscar
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Ortiz, Pablo
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Mato, Jose M.
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Dufour, Jean-Fra ...
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Oresic, Matej, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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Nature Reviews. ...
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Örebro University