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Attention-deficit/h...
Attention-deficit/hyperactivity disorder and Alzheimer's disease and any dementia : A multi-generation cohort study in Sweden
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- Zhang, Le (author)
- Karolinska Institutet
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- Du Rietz, Ebba (author)
- Karolinska Institutet
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- Kuja-Halkola, Ralf (author)
- Karolinska Institutet
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- Dobrosavljevic, Maja, 1986- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Johnell, Kristina (author)
- Karolinska Institutet
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- Pedersen, Nancy L. (author)
- Karolinska Institutet
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- Larsson, Henrik, 1975- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Chang, Zheng (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-09-09
- 2022
- English.
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In: Alzheimer's & Dementia. - : John Wiley & Sons. - 1552-5260 .- 1552-5279. ; 18:6, s. 1155-1163
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Abstract
Subject headings
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- INTRODUCTION: We examined the extent to which attention-deficit/hyperactivity disorder (ADHD), a neurodevelopmental disorder, is linked with Alzheimer's disease (AD) and any dementia, neurodegenerative diseases, across generations.METHODS: A nationwide cohort born between 1980 and 2001 (index persons) were linked to their biological relatives (parents, grandparents, uncles/aunts) using Swedish national registers. We used Cox models to examine the cross-generation associations.RESULTS: Among relatives of 2,132,929 index persons, 3042 parents, 171,732 grandparents, and 1369 uncles/aunts had a diagnosis of AD. Parents of individuals with ADHD had an increased risk of AD (hazard ratio 1.55, 95% confidence interval 1.26-1.89). The associations attenuated but remained elevated in grandparents and uncles/aunts. The association for early-onset AD was stronger than late-onset AD. Similar results were observed for any dementia.DISCUSSION: ADHD is associated with AD and any dementia across generations. The associations attenuated with decreasing genetic relatedness, suggesting shared familial risk between ADHD and AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Alzheimer's disease
- dementia
- epidemiology
- family design
- neurodevelopmental disorder
Publication and Content Type
- ref (subject category)
- art (subject category)
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