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Mortality in Eosino...
Mortality in Eosinophilic Esophagitis - a nationwide, population-based matched cohort study from 2005 to 2017
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- Röjler, Lovisa, 1983- (author)
- Department of Pediatrics, Örebro University Hospital, Sweden
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- Garber, John J. (author)
- Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA
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- Roelstraete, Bjorn (author)
- Karolinska Institutet
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- Walker, Marjorie M. (author)
- Department Anatomical Pathology, University of Newcastle, Faculty of Health and Medicine, School of Medicine and Public Health Callaghan NSW, Australia
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- Ludvigsson, Jonas F., 1969- (author)
- Karolinska Institutet,Region Örebro län,Department of Pediatrics, Örebro University Hospital, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, City Hospital, Nottingham, UK; Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA
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(creator_code:org_t)
- 2021-08-31
- 2021
- English.
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In: Upsala Journal of Medical Sciences. - : Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 126:1
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https://doi.org/10.4...
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https://ujms.net/ind...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: There is a lack of knowledge about mortality in eosinophilic esophagitis (EoE). Therefore, this study aimed to examine the mortality in EoE.Methods: A nationwide, population- based matched cohort study was conducted of all EoE patients in Sweden diagnosed between July 2005 and December 2017. Individuals with EoE (n = 1,625) were identified through prospectively recorded histopathology codes from all gastrointestinal pathology-reports in Sweden, representing 28 pathology departments (the ESPRESSO study). Each individual with EoE was then matched with up to five reference individuals from the general population (n = 8,003) for age, sex, year of birth, and place of residence. We used the Cox proportional hazard modeling to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (95% CI) while adjusting for other potential confounders. In sensitivity analyses, mortality in EoE patients was compared with mortality in their siblings.Results: Through December 2017, 34 deaths were confirmed in EoE patients (4.60 per 1,000 person-years) compared with 165 in reference individuals (4.57 per 1,000 person-years). This rate corresponds to an aHR of 0.97 (95% CI = 0.67-1.40). HRs were similar in males (aHR = 1.00 [0.66-1.51]) and females (aHR = 0.92 [0.38-2.18]). We observed no increased risk in mortality due to esophageal or other gastrointestinal cancers in patients with EoE (aHR = 1.02 [0.51- 2.02]). Mortality was similar in EoE patients and their siblings (aHR = 0.91 [0.44-1.85]).Conclusion: In this nationwide, population-based matched cohort study in Sweden, there was no -increased risk of death in patients with EoE compared with their siblings and the general population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- death
- cancer
- eosinophilic esophagitis
- mortality
- population-based
Publication and Content Type
- ref (subject category)
- art (subject category)
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