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  • Berntorp, KarolinaLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital (author)

Instantaneous wave-free ratio compared with fractional flow reserve in PCI : A cost-minimization analysis

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Hindawi Publishing Corporation,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-94784
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-94784URI
  • https://doi.org/10.1016/j.ijcard.2021.09.054DOI
  • https://lup.lub.lu.se/record/631070a7-08f9-413e-acec-375226b97981URI
  • https://gup.ub.gu.se/publication/308271URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agency:Philips Volcano
  • BACKGROUND: Coronary physiology is a routine diagnostic tool when assessing whether coronary revascularization is indicated. The iFR-SWEDEHEART trial demonstrated similar clinical outcomes when using instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) to guide revascularization. The objective of this analysis was to assess a cost-minimization analysis of iFR-guided compared with FFR-guided revascularization.METHODS: In this cost-minimization analysis we used a decision-tree model from a healthcare perspective with a time-horizon of one year to estimate the cost difference between iFR and FFR in a Nordic setting and a United States (US) setting. Treatment pathways and health care utilizations were constructed from the iFR-SWEDEHEART trial. Unit cost for revascularization and myocardial infarction in the Nordic setting and US setting were derived from the Nordic diagnosis-related group versus Medicare cost data. Unit cost of intravenous adenosine administration and cost per stent placed were based on the average costs from the enrolled centers in the iFR-SWEDEHEART trial. Deterministic and probabilistic sensitivity analyses were carried out to test the robustness of the result.RESULTS: The cost-minimization analysis demonstrated a cost saving per patient of $681 (95% CI: $641 - $723) in the Nordic setting and $1024 (95% CI: $934 - $1114) in the US setting, when using iFR-guided compared with FFR-guided revascularization. The results were not sensitive to changes in uncertain parameters or assumptions.CONCLUSIONS: IFR-guided revascularization is associated with significant savings in cost compared with FFR-guided revascularization.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Persson, Josefine,1981Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xpejos (author)
  • Koul, Sasha M.Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-sku (author)
  • Patel, Manesh R.Duke University, Durham, NC, United States (author)
  • Christiansen, Evald H.Department of Cardiology, Aarhus University Hospital, Skejby, Denmark (author)
  • Gudmundsdottir, IngibjörgDepartment of Cardiology, Reykjavik University Hospital and University of Iceland, Reykjavik, Iceland (author)
  • Yndigegn, TroelsLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-toy (author)
  • Omerovic, Elmir,1968Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xomeel (author)
  • Erlinge, DavidLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)kard-der (author)
  • Fröbert, Ole,1964-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology(Swepub:oru)oft (author)
  • Götberg, MatthiasLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)kard-mgo (author)
  • KardiologiSektion II (creator_code:org_t)

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  • In:International Journal of Cardiology: Hindawi Publishing Corporation344, s. 54-590167-52731874-1754

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