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Performance of crea...
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Delanaye, PierreDepartment of Nephrology-Dialysis-Transplantation, University of Liège (ULg CHU), CHU Sart Tilman, Liège, Belgium; Department of Nephrology-Dialysis-Apheresis, Hopital Universitaire Caremeau, Nimes, France
(author)
Performance of creatinine-based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2021-12-03
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Wiley-Blackwell Publishing Inc.2022
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-95277
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-95277URI
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https://doi.org/10.1111/bcp.15132DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148240454URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457614URI
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https://lup.lub.lu.se/record/c2a98b97-9be3-441c-9fbd-00722d5b35c6URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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AIM: The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing METHODS: In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14,804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), Chronic-Kidney-Disease-Epidemiology (CKD-EPI), Lund-Malmö-Revised (LMR), and European-Kidney-Function-Consortium (EKFC) equations. Validation focused on bias, imprecision, and accuracy (percentage of estimates within ±30% of mGFR, P30), overall and stratified for mGFR, age, and body mass index at mGFR <60 mL/min, as well as classification in mGFR stages.RESULTS: The CG equation performed worse than the other equations, overall and in mGFR, age and BMI subgroups in terms of bias (systematic overestimation), imprecision and accuracy except for patients ≥65 years where bias and P30 were similar to MDRD and CKD-EPI, but worse than LMR and EKFC. In subjects with mGFR<60 mL/min and at BMI [18.5-25[kg/m2 , all equations performed similarly and for BMI<18.5kg/m2 CG and LMR had the best results though all equations had poor P30-accuracy. At BMI≥25kg/m2 the bias of the CG increased with increasing BMI (+17.2mL/min at BMI≥40kg/m2 ). The four more recent equations also classified mGFR stages better than CG.CONCLUSIONS: The CG equation showed poor ability to estimate GFR overall and in analyses stratified for GFR, age, and BMI. CG was inferior to correctly classify the patients in the mGFR staging compared to more recent creatinine-based equations.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Björk, JonasLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)ymed-jbj
(author)
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Courbebaisse, MariePhysiology Department, Georges Pompidou European Hospital, Assistance Publique Hôpitaux de Paris, Paris Descartes University, INSERM U1151-CNRS UMR8253, Paris, France.,Paris Diderot University
(author)
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Couzi, LionelCHU de Bordeaux, Nephrologie - Transplantation - Dialyse, Université de Bordeaux, CNRS-UMR 5164 Immuno ConcEpT, France.
(author)
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Ebert, NatalieCharité Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany.,Charité - University Medicine Berlin
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Eriksen, Björn O.Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsö, Norway.
(author)
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Dalton, R NeilThe Wellchild Laboratory, Evelina London Children's Hospital, London, United Kingdom.,Evelina London Children's Healthcare
(author)
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Dubourg, LaurenceNéphrologie, Dialyse, Hypertension et Exploration Fonctionnelle Rénale, Hôpital Edouard Herriot, Hospices Civils de Lyon, France.,Claude Bernard University Lyon 1
(author)
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Gaillard, FrancoisRenal Transplantation Department, Assistance Publique-Hôpitaux de Paris (AP-HP), France,Hôpital Edouard Herriot
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Garrouste, CyrilDepartment of Nephrology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.
(author)
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Grubb, AndersLund University,Lunds universitet,Cystatin C, njursjukdom, amyloidos och antibiotika,Forskargrupper vid Lunds universitet,Cystatin C, renal disease, amyloidosis and antibiotics,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kkem-agr
(author)
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Jacquemont, LolaRenal Transplantation Department, CHU Nantes, Nantes University, Nantes, France.,University of Nantes
(author)
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Hansson, MagnusKarolinska Institute,Karolinska Institutet,Function area Clinical Chemistry, Karolinska University Laboratory, Karolinska University Hospital Huddinge and Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
(author)
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Kamar, NassimDepartment of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, INSERM U1043, IFR -BMT, University Paul Sabatier, Toulouse, France.,Rangueil Hospital
(author)
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Lamb, Edmund J.Clinical Biochemistry, East Kent Hospitals University NHS Foundation Trust, Canterbury, United Kingdom.
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Legendre, ChristopheHôpital Necker, AP-HP & Université Paris Descartes, Paris, France.,Necker-Enfants Malades Hospital
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Littmann, KarinKarolinska Institute,Karolinska Institutet,Department of Medicine Huddinge (MedH), Karolinska Institute, Huddinge, Sweden.
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Mariat, ChristopheService de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Nord, CHU de Saint-Etienne, France.
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Melsom, ToralfMetabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsö, Norway,Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, Hôpital Michallon, CHU Grenoble-Alpes, France.
(author)
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Rostaing, LionelService de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, Hôpital Michallon, CHU Grenoble-Alpes, France,Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.,Grenoble University Hospital
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Rule, Andrew D.Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.,Mayo Clinic Minnesota
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Schaeffner, ElkeCharité Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany,Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.,Charité - University Medicine Berlin
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Sundin, Per-Ola,1971-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Geriatrics, School of Medical Sciences, Örebro University, Örebro, Sweden.(Swepub:oru)pasn
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Berg, UllaKarolinska Institutet,Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
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Åsling-Monemi, KajsaDepartment of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
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Selistre, LucianoMestrado em Ciências da Saúde -Universidade Caxias do Sul Foundation CAPES, Brazil.,University of Caxias do Sul
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Åkesson, AnnaLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,EPI@LUND,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups(Swepub:lu)stat-aas
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Larsson, AndersUppsala universitet,Klinisk kemi,Academic Medical Center of University of Amsterdam (AMC)(Swepub:uu)andlarss
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Bökenkamp, ArendUppsala University
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Pottel, HansDepartment of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.,Catholic University of Leuven
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Nyman, UlfLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Radiology Diagnostics, Malmö,Lund University Research Groups(Swepub:lu)ront-uny
(author)
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Department of Nephrology-Dialysis-Transplantation, University of Liège (ULg CHU), CHU Sart Tilman, Liège, Belgium; Department of Nephrology-Dialysis-Apheresis, Hopital Universitaire Caremeau, Nimes, FranceAvdelningen för arbets- och miljömedicin
(creator_code:org_t)
Related titles
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In:British Journal of Clinical Pharmacology: Wiley-Blackwell Publishing Inc.88:5, s. 2118-21270306-52511365-2125
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Delanaye, Pierre
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Björk, Jonas
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Courbebaisse, Ma ...
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Couzi, Lionel
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Ebert, Natalie
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Eriksen, Björn O ...
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Dalton, R Neil
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Dubourg, Laurenc ...
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Gaillard, Franco ...
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Garrouste, Cyril
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Grubb, Anders
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Jacquemont, Lola
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Hansson, Magnus
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Kamar, Nassim
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Lamb, Edmund J.
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Legendre, Christ ...
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Littmann, Karin
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Mariat, Christop ...
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Melsom, Toralf
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Rostaing, Lionel
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Rule, Andrew D.
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Schaeffner, Elke
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Sundin, Per-Ola, ...
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Berg, Ulla
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Åsling-Monemi, K ...
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Selistre, Lucian ...
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Åkesson, Anna
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Larsson, Anders
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Bökenkamp, Arend
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Pottel, Hans
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Nyman, Ulf
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