Statin Therapy is Associated with Decreased 90-day Postoperative Mortality After Colon Cancer Surgery

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Pourlotfi, Arvid,1995-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Örebro University Hospital, Örebro, Sweden (author)

Statin Therapy is Associated with Decreased 90-day Postoperative Mortality After Colon Cancer Surgery

Article/chapterEnglish2022

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Springer,2022
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LIBRIS-ID:oai:DiVA.org:oru-95511
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-95511URI
https://doi.org/10.1097/DCR.0000000000001933DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:149570359URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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BACKGROUND: There have been conflicting reports regarding a protective effect of statin therapy after colon cancer surgery.OBJECTIVE: This study aimed to evaluate the association between statin therapy and the postoperative mortality following elective colon cancer surgery.DESIGN: This population-based cohort study is a retrospective analysis of prospectively collected data from the Swedish Colorectal Cancer Register.SETTINGS: Patient inclusion was achieved by inclusion through a nationwide register.PATIENTS: All adult patients undergoing elective surgery for colon cancer between the period of January 2007 and September 2016 were included in the study. Patients who had received and collected a prescription for statins pre- and postoperatively were allocated to the statin positive cohort.MAIN OUTCOME MEASURES: The primary and secondary outcomes of interest were 90-day all-cause mortality and 90-day cause-specific mortality.RESULTS: A total of 22,337 patients underwent elective surgery for colon cancer during the study period, of whom 6,494 (29%) were classified as statin users. Statin users displayed a significant survival benefit despite being older, having a higher comorbidity burden, and less fit for surgery. Multivariate analysis illustrated significant reductions in the incidence risk for 90-day all-cause mortality (Incidence Rate Ratio = 0.12, p < 0.001) as well as 90-day cause-specific deaths due to sepsis, multiorgan failure, or of cardiovascular and respiratory origin.LIMITATIONS: The limitations of this study include its observational retrospective design, restricting the ability to perform standardized follow-up of statin therapy. Confounding from other uncontrolled variables cannot be excluded.CONCLUSIONS: Statin users had a significant postoperative benefit regarding short-term mortality following elective colon cancer surgery in the current study, however, further research is needed to ascertain if this relationship is causal. See Video Abstract at http://links.lww.com/DCR/B738.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
Colon cancer
Mortality
Postoperative
Statins
Surgery

Added entries (persons, corporate bodies, meetings, titles ...)

Ahl, Rebecka,1987-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Karolinska University Hospital, Stockholm, Sweden(Swepub:oru)raal (author)
Bass, Gary Alan,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Surgical Critical Care & Emergency Surgery, Penn Medicine, Penn Presbyterian Medical Center, Philadelphia, USA(Swepub:oru)gbs (author)
Sjölin, Gabriel,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery, Örebro University Hospital, Örebro, Sweden(Swepub:oru)glsn (author)
Cao, Yang,Associate Professor,1972-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics(Swepub:oru)yco (author)
Matthiessen, Peter,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Örebro University Hospital, Örebro, Sweden(Swepub:oru)pemn (author)
Mohseni, Shahin,1978-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery, Örebro University Hospital, Örebro, Sweden(Swepub:oru)snmi (author)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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In:Diseases of the Colon & Rectum: Springer65:4, s. 559-5650012-37061530-0358

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