Evaluation of dyskerin expression and the Cajal body protein WRAP53β as potential prognostic markers for patients with primary vaginal carcinoma

Ranhem, Cecilia (author): Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Centre for Clinical Research Region Västmanland, Uppsala University, Västmanlands Hospital Västerås, Västerås, Sweden

Lillsunde-Larsson, Gabriella, 1971- (author): Örebro universitet,Institutionen för hälsovetenskaper,Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden

Lindqvist, David (author): Department of Radiation Sciences, Umeå Universitet, Umeå, Sweden

Sorbe, Bengt (author): Department of Oncology, Örebro University Hospital, Örebro, Sweden

Karlsson, Mats, 1960- (author): Örebro universitet,Institutionen för medicinska vetenskaper

Hellman, Kristina (author): Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

Kovaleska, Larysa (author): R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of National Academy of Sciences of Ukraine, Kiev, Ukraine

Andersson, Sonia (author): Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden

(creator_code:org_t)

2021-11-23
2022
English.
In: Oncology Letters. - : Spandidos Publications. - 1792-1074 .- 1792-1082. ; 23:1

Related links:: https://doi.org/10.3...; show more...; https://www.spandido...; https://urn.kb.se/re...; https://doi.org/10.3...; http://kipublication...; show less...

Abstract Subject headings

Primary vaginal cancer (PVC) is a rare gynaecological malignancy, which, at present, lacks appropriate biomarkers for prognosis. The proteins dyskerin and WD repeat containing antisense to TP53 (WRAP53β), both of which exert their functions in the telomerase holoenzyme complex, have been shown to be upregulated in different cancer types. These proteins have also been proposed as prognostic markers in some types of cancer. The aim of the present study was to examine the expression patterns of dyskerin and WRAP53β in patients with PVC. Moreover, as part of a search for effective biomarkers to evaluate prognosis in PVC, the expression of these two proteins and their potential association with clinical variables and survival were also evaluated. The expression of dyskerin and WRAP53β was assessed in PVC tumour samples from 68 patients using immunohistochemistry. The majority of tumour samples showed low and moderate expression levels of dyskerin. Upregulation of dyskerin in tumour samples was significantly associated with a shorter survival time and a poorer cancer-specific survival rate. WRAP53β was also expressed in most of the cells but was not significantly associated with clinical variables or survival. This study demonstrates that upregulation of dyskerin is significantly associated with poor prognosis. Thus, dyskerin may serve as a promising prognostic marker and a potential putative therapeutic target in PVC.

By the author/editor: Ranhem, Cecilia; Lillsunde-Larsso ...; Lindqvist, David; Sorbe, Bengt; Karlsson, Mats, ...; Farnebo, Mariann ...; show more...; Hellman, Kristin ...; Kovaleska, Larys ...; Kashuba, Elena; Andersson, Sonia; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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