Search: onr:"swepub:oai:DiVA.org:oru-96401" >
Associations of par...
Associations of parental and perinatal factors with subsequent risk of stress-related disorders : a nationwide cohort study with sibling comparison
-
- Li, Yuchen (author)
- Mental Health Center, West China Hospital of Sichuan University, Chengdu, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
-
- Sjölander, Arvid (author)
- Karolinska Institutet
-
- Song, Huan (author)
- West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China; Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland
-
show more...
-
- Cnattingius, Sven (author)
- Karolinska Institutet
-
- Fang, Fang (author)
- Karolinska Institutet
-
- Yang, Qian (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
-
- de la Cruz, Lorena Fernández (author)
- Karolinska Institutet
-
- Mataix-Cols, David (author)
- Karolinska Institutet
-
- Brander, Gustaf (author)
- Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
-
- Li, Jiong (author)
- Department of Clinical Medicine-Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark
-
- Zhang, Wei (author)
- Mental Health Center, West China Hospital of Sichuan University, Chengdu, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China
-
- Fall, Katja, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden
-
- D'Onofrio, Brian M. (author)
- Karolinska Institutet
-
- Almqvist, Catarina (author)
- Karolinska Institutet
-
- Lichtenstein, Paul (author)
- Karolinska Institutet
-
- Valdimarsdottir, Unnur A. (author)
- Karolinska Institutet
-
- Lu, Donghao (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2022-01-01
- 2022
- English.
-
In: Molecular Psychiatry. - : Springer Nature. - 1359-4184 .- 1476-5578. ; 27, s. 1712-1719
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://www.nature.c...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Little is known about the contribution of pregnancy-related parental and perinatal factors to the development of stress-related disorders. We aimed to investigate whether parental/perinatal adversities entail higher risks of stress-related disorders in the offspring, later in life, by accounting for genetic and early environmental factors. Based on the nationwide Swedish registers, we conducted a population-based cohort study of 3,435,747 singleton births (of which 2,554,235 were full siblings), born 1973-2008 and survived through the age of 5 years. Using both population- and sibling designs, we employed Cox regression to assess the association between parental and perinatal factors with subsequent risk of stress-related disorders. We identified 55,511 individuals diagnosed with stress-related disorders in the population analysis and 37,433 in the sibling analysis. In the population-based analysis we observed increased risks of stress-related disorders among offspring of maternal/paternal age <25, single mothers, parity >= 4, mothers with BMI >= 25 or maternal smoking in early pregnancy, gestational diabetes, and offspring born moderately preterm (GA 32-36 weeks), or small-for-gestational-age. These associations were significantly attenuated toward null in the sibling analysis. Cesarean-section was weakly associated with offspring stress-related disorders in population [hazard ratio (HR) 1.09, 95% confidence interval (CI) 1.06-1.12] and sibling analyses (HR 1.10, 95% CI 1.02-1.20). Our findings suggest that most of the observed associations between parental and perinatal factors and risk of stress-related disorders in the population analysis are driven by shared familial environment or genetics, and underscore the importance of family designs in epidemiological studies on the etiology of psychiatric disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Li, Yuchen
-
Sjölander, Arvid
-
Song, Huan
-
Cnattingius, Sve ...
-
Fang, Fang
-
Yang, Qian
-
show more...
-
de la Cruz, Lore ...
-
Mataix-Cols, Dav ...
-
Brander, Gustaf
-
Li, Jiong
-
Zhang, Wei
-
Fall, Katja, 197 ...
-
D'Onofrio, Brian ...
-
Almqvist, Catari ...
-
Lichtenstein, Pa ...
-
Valdimarsdottir, ...
-
Lu, Donghao
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
- Articles in the publication
-
Molecular Psychi ...
- By the university
-
Örebro University
-
Karolinska Institutet