Search: onr:"swepub:oai:DiVA.org:oru-96436" > Racemic Ketamine as...
Fältnamn | Indikatorer | Metadata |
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000 | 07326naa a2200613 4500 | |
001 | oai:DiVA.org:oru-96436 | |
003 | SwePub | |
008 | 220113s2022 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:5106fb3d-8fdc-44eb-9b0b-6567ca84d9e9 | |
009 | oai:DiVA.org:liu-184969 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-964362 URI |
024 | 7 | a https://doi.org/10.1093/ijnp/pyab0882 DOI |
024 | 7 | a https://lup.lub.lu.se/record/5106fb3d-8fdc-44eb-9b0b-6567ca84d9e92 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1849692 URI |
040 | a (SwePub)orud (SwePub)lud (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ekstrand, Joakimu Lund University,Lunds universitet,Enheten för psykiatrisk neuromodulering (PNU),Forskargrupper vid Lunds universitet,Psychiatric Neuromodulation Unit (PNU),Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)mpu-jek |
245 | 1 0 | a Racemic Ketamine as an Alternative to Electroconvulsive Therapy for Unipolar Depression :b A Randomized, Open-Label, Non-Inferiority Trial (KetECT) |
264 | c 2021-12-04 | |
264 | 1 | b Oxford University Press,c 2022 |
338 | a print2 rdacarrier | |
500 | a Funding agencies:Königska FoundationLions forsknings foundation SkåneOM Perssons donation foundation | |
500 | a Funding Agencies|Swedish Research Council [2015-00799]; Crafoord Foundation; Skane Regional Council; Konigska Foundation; Lions forsknings foundation Skane; OM Perssons donation foundation | |
520 | a BACKGROUND: Ketamine has emerged as a fast-acting and powerful antidepressant, but no head to head trial has been performed, Here, ketamine is compared with electroconvulsive therapy (ECT), the most effective therapy for depression.METHODS: Hospitalized patients with unipolar depression were randomized (1:1) to thrice-weekly racemic ketamine (0.5 mg/kg) infusions or ECT in a parallel, open-label, non-inferiority study. The primary outcome was remission (Montgomery Åsberg Depression Rating Scale score ≤10). Secondary outcomes included adverse events (AEs), time to remission, and relapse. Treatment sessions (maximum of 12) were administered until remission or maximal effect was achieved. Remitters were followed for 12 months after the final treatment session.RESULTS: In total 186 inpatients were included and received treatment. Among patients receiving ECT, 63% remitted compared with 46% receiving ketamine infusions (P = .026; difference 95% CI 2%, 30%). Both ketamine and ECT required a median of 6 treatment sessions to induce remission. Distinct AEs were associated with each treatment. Serious and long-lasting AEs, including cases of persisting amnesia, were more common with ECT, while treatment-emergent AEs led to more dropouts in the ketamine group. Among remitters, 70% and 63%, with 57 and 61 median days in remission, relapsed within 12 months in the ketamine and ECT groups, respectively (P = .52).CONCLUSION: Remission and cumulative symptom reduction following multiple racemic ketamine infusions in severely ill patients (age 18-85 years) in an authentic clinical setting suggest that ketamine, despite being inferior to ECT, can be a safe and valuable tool in treating unipolar depression. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
653 | a Electroconvulsive therapy | |
653 | a ketamine infusion | |
653 | a major depressive disorder | |
653 | a psychotic depression | |
653 | a racemic ketamine | |
653 | a Electroconvulsive therapy, ketamine infusion, major depressive disorder, psychotic depression, racemic ketamine | |
700 | 1 | a Fattah, Christianu Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden,Lund Univ, Sweden4 aut |
700 | 1 | a Persson, Marcusu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden4 aut0 (Swepub:lu)ma4184pe |
700 | 1 | a Cheng, Tonyu Lund University,Lunds universitet,Psykiatri,Forskargrupper vid Lunds universitet,Psychiatry,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)to0337ch |
700 | 1 | a Nordanskog, Pia,d 1971-u Linköpings universitet,Linköping University,Centrum för social och affektiv neurovetenskap (CSAN),Medicinska fakulteten,Centrum för social och affektiv neurovetenskap,Region Östergötland, Psykiatriska kliniken i Linköping4 aut0 (Swepub:liu)piano33 |
700 | 1 | a Åkeson, Jonasu Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)kir-jak |
700 | 1 | a Tingström, Andersu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för psykiatrisk neuromodulering (PNU),Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Psychiatric Neuromodulation Unit (PNU),Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)mpu-ati |
700 | 1 | a Lindström, Matsu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Psykiatri,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Psychiatry,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)psyk-ml0 |
700 | 1 | a Nordenskjöld, Axel,d 1977-u Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Sweden4 aut0 (Swepub:oru)alnd |
700 | 1 | a Movahed, Rad Pouyau Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för psykiatrisk neuromodulering (PNU),Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Psychiatric Neuromodulation Unit (PNU),Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)kfar-pmo |
710 | 2 | a Enheten för psykiatrisk neuromodulering (PNU)b Forskargrupper vid Lunds universitet4 org |
773 | 0 | t International Journal of Neuropsychopharmacologyd : Oxford University Pressg 25:5, s. 339-349q 25:5<339-349x 1461-1457x 1469-5111 |
856 | 4 | u https://doi.org/10.1093/ijnp/pyab088y Fulltext |
856 | 4 | u https://academic.oup.com/ijnp/advance-article-pdf/doi/10.1093/ijnp/pyab088/42136943/pyab088.pdf |
856 | 4 | u http://dx.doi.org/10.1093/ijnp/pyab088x freey FULLTEXT |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1658328/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-96436 |
856 | 4 8 | u https://doi.org/10.1093/ijnp/pyab088 |
856 | 4 8 | u https://lup.lub.lu.se/record/5106fb3d-8fdc-44eb-9b0b-6567ca84d9e9 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-184969 |
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