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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007326naa a2200613 4500
001oai:DiVA.org:oru-96436
003SwePub
008220113s2022 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:5106fb3d-8fdc-44eb-9b0b-6567ca84d9e9
009oai:DiVA.org:liu-184969
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-964362 URI
0247 a https://doi.org/10.1093/ijnp/pyab0882 DOI
0247 a https://lup.lub.lu.se/record/5106fb3d-8fdc-44eb-9b0b-6567ca84d9e92 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1849692 URI
040 a (SwePub)orud (SwePub)lud (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ekstrand, Joakimu Lund University,Lunds universitet,Enheten för psykiatrisk neuromodulering (PNU),Forskargrupper vid Lunds universitet,Psychiatric Neuromodulation Unit (PNU),Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)mpu-jek
2451 0a Racemic Ketamine as an Alternative to Electroconvulsive Therapy for Unipolar Depression :b A Randomized, Open-Label, Non-Inferiority Trial (KetECT)
264 c 2021-12-04
264 1b Oxford University Press,c 2022
338 a print2 rdacarrier
500 a Funding agencies:Königska FoundationLions forsknings foundation SkåneOM Perssons donation foundation
500 a Funding Agencies|Swedish Research Council [2015-00799]; Crafoord Foundation; Skane Regional Council; Konigska Foundation; Lions forsknings foundation Skane; OM Perssons donation foundation
520 a BACKGROUND: Ketamine has emerged as a fast-acting and powerful antidepressant, but no head to head trial has been performed, Here, ketamine is compared with electroconvulsive therapy (ECT), the most effective therapy for depression.METHODS: Hospitalized patients with unipolar depression were randomized (1:1) to thrice-weekly racemic ketamine (0.5 mg/kg) infusions or ECT in a parallel, open-label, non-inferiority study. The primary outcome was remission (Montgomery Åsberg Depression Rating Scale score ≤10). Secondary outcomes included adverse events (AEs), time to remission, and relapse. Treatment sessions (maximum of 12) were administered until remission or maximal effect was achieved. Remitters were followed for 12 months after the final treatment session.RESULTS: In total 186 inpatients were included and received treatment. Among patients receiving ECT, 63% remitted compared with 46% receiving ketamine infusions (P = .026; difference 95% CI 2%, 30%). Both ketamine and ECT required a median of 6 treatment sessions to induce remission. Distinct AEs were associated with each treatment. Serious and long-lasting AEs, including cases of persisting amnesia, were more common with ECT, while treatment-emergent AEs led to more dropouts in the ketamine group. Among remitters, 70% and 63%, with 57 and 61 median days in remission, relapsed within 12 months in the ketamine and ECT groups, respectively (P = .52).CONCLUSION: Remission and cumulative symptom reduction following multiple racemic ketamine infusions in severely ill patients (age 18-85 years) in an authentic clinical setting suggest that ketamine, despite being inferior to ECT, can be a safe and valuable tool in treating unipolar depression.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653 a Electroconvulsive therapy
653 a ketamine infusion
653 a major depressive disorder
653 a psychotic depression
653 a racemic ketamine
653 a Electroconvulsive therapy, ketamine infusion, major depressive disorder, psychotic depression, racemic ketamine
7001 a Fattah, Christianu Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden,Lund Univ, Sweden4 aut
7001 a Persson, Marcusu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden4 aut0 (Swepub:lu)ma4184pe
7001 a Cheng, Tonyu Lund University,Lunds universitet,Psykiatri,Forskargrupper vid Lunds universitet,Psychiatry,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)to0337ch
7001 a Nordanskog, Pia,d 1971-u Linköpings universitet,Linköping University,Centrum för social och affektiv neurovetenskap (CSAN),Medicinska fakulteten,Centrum för social och affektiv neurovetenskap,Region Östergötland, Psykiatriska kliniken i Linköping4 aut0 (Swepub:liu)piano33
7001 a Åkeson, Jonasu Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)kir-jak
7001 a Tingström, Andersu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för psykiatrisk neuromodulering (PNU),Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Psychiatric Neuromodulation Unit (PNU),Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)mpu-ati
7001 a Lindström, Matsu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Psykiatri,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Psychiatry,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)psyk-ml0
7001 a Nordenskjöld, Axel,d 1977-u Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Sweden4 aut0 (Swepub:oru)alnd
7001 a Movahed, Rad Pouyau Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för psykiatrisk neuromodulering (PNU),Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Psychiatric Neuromodulation Unit (PNU),Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)kfar-pmo
7102 a Enheten för psykiatrisk neuromodulering (PNU)b Forskargrupper vid Lunds universitet4 org
7730 t International Journal of Neuropsychopharmacologyd : Oxford University Pressg 25:5, s. 339-349q 25:5<339-349x 1461-1457x 1469-5111
8564 u https://doi.org/10.1093/ijnp/pyab088y Fulltext
8564 u https://academic.oup.com/ijnp/advance-article-pdf/doi/10.1093/ijnp/pyab088/42136943/pyab088.pdf
8564 u http://dx.doi.org/10.1093/ijnp/pyab088x freey FULLTEXT
8564 u https://liu.diva-portal.org/smash/get/diva2:1658328/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-96436
8564 8u https://doi.org/10.1093/ijnp/pyab088
8564 8u https://lup.lub.lu.se/record/5106fb3d-8fdc-44eb-9b0b-6567ca84d9e9
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-184969

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