Search: onr:"swepub:oai:DiVA.org:oru-96668" > Analysis of the SYS...
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001 | oai:DiVA.org:oru-96668 | |
003 | SwePub | |
008 | 220125s2021 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-469771 | |
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024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-966682 URI |
024 | 7 | a https://doi.org/10.1016/j.clnu.2021.12.0312 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4697712 URI |
024 | 7 | a https://lup.lub.lu.se/record/6bf86c9b-94ac-4a6f-8b58-105864cf0ab42 URI |
040 | a (SwePub)orud (SwePub)uud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gürdeniz, Gözdeu Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark; Department of Food Science, University of Copenhagen, Frederiksberg, Denmark,Univ Copenhagen, Dept Nutr Exercise & Sports, Frederiksberg, Denmark.;Univ Copenhagen, Dept Food Sci, Frederiksberg, Denmark4 aut |
245 | 1 0 | a Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids |
264 | 1 | b Elsevier,c 2021 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND & AIMS: Intake assessment in multicenter trials is challenging, yet important for accurate outcome evaluation. The present study aimed to characterize a multicenter randomized controlled trial with a healthy Nordic diet (HND) compared to a Control diet (CD) by plasma and urine metabolic profiles and to associate them with cardiometabolic markers.METHODS: During 18-24 weeks of intervention, 200 participants with metabolic syndrome were advised at six centres to eat either HND (e.g. whole-grain products, berries, rapeseed oil, fish and low-fat dairy) or CD while being weight stable. Of these 166/159 completers delivered blood/urine samples. Metabolic profiles of fasting plasma and 24 h pooled urine were analysed to identify characteristic diet-related patterns. Principal components analysis (PCA) scores (i.e. PC1 and PC2 scores) were used to test their combined effect on blood glucose response (primary endpoint), serum lipoproteins, triglycerides, and inflammatory markers.RESULTS: The profiles distinguished HND and CD with AUC of 0.96 ± 0.03 and 0.93 ± 0.02 for plasma and urine, respectively, with limited heterogeneity between centers, reflecting markers of key foods. Markers of fish, whole grain and polyunsaturated lipids characterized HND, while CD was reflected by lipids containing palmitoleic acid. The PC1 scores of plasma metabolites characterizing the intervention is associated with HDL (β = 0.05; 95% CI: 0.02, 0.08; P = 0.001) and triglycerides (β = -0.06; 95% CI: -0.09, -0.03; P < 0.001). PC2 scores were related with glucose metabolism (2 h Glucose, β = 0.1; 95% CI: 0.05, 0.15; P < 0.001), LDL (β = 0.06; 95% CI: 0.01, 0.1; P = 0.02) and triglycerides (β = 0.11; 95% CI: 0.06, 0.15; P < 0.001). For urine, the scores were related with LDL cholesterol.CONCLUSIONS: Plasma and urine metabolite profiles from SYSDIET reflected good compliance with dietary recommendations across the region. The scores of metabolites characterizing the diets associated with outcomes related with cardio-metabolic risk. Our analysis therefore offers a novel way to approach a per protocol analysis with a balanced compliance assessment in larger multicentre dietary trials. The study was registered at clinicaltrials.gov with NCT00992641. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
653 | a Glucose and lipid metabolism | |
653 | a Healthy Nordic diet | |
653 | a LC–MS metabolomics | |
653 | a Plasma metabolite scores | |
653 | a Randomized controlled trial | |
653 | a Glucose and lipid metabolism | |
653 | a Healthy Nordic diet | |
653 | a LC–MS metabolomics | |
653 | a Plasma metabolite scores | |
653 | a Randomized controlled trial | |
700 | 1 | a Uusitupa, Mattiu Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland4 aut |
700 | 1 | a Hermansen, Kjeldu Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Aarhus, Denmark4 aut |
700 | 1 | a Savolainen, Markku J.u Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland,Univ Oulu, Inst Clin Med, Dept Internal Med, Oulu, Finland4 aut |
700 | 1 | a Schwab, Ursulau Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;Kuopio Univ Hosp, Dept Med Endocrinol & Clin Nutr, Kuopio, Finland4 aut |
700 | 1 | a Kolehmainen, Marjukkau Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland4 aut |
700 | 1 | a Brader, Leau Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Aarhus, Denmark4 aut |
700 | 1 | a Cloetens, Lieselotteu Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)tbio-lce |
700 | 1 | a Herzig, Karl-Heinzu Institute of Biomedicine and Biocenter of Oulu, University of Oulu, Finland; Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland,Univ Oulu, Inst Biomed, Oulu, Finland.;Univ Oulu, Bioctr Oulu, Oulu, Finland.;Kuopio Univ Hosp, Dept Psychiat, Kuopio, Finland4 aut |
700 | 1 | a Hukkanen, Janneu Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland,Univ Oulu, Inst Clin Med, Dept Internal Med, Oulu, Finland4 aut |
700 | 1 | a Rosqvist, Fredrik,d 1985-u Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap4 aut0 (Swepub:uu)frero353 |
700 | 1 | a Ulven, Stine Marieu Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway,Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway4 aut |
700 | 1 | a Gunnarsdóttir, Ingibjörgu Unit for Nutrition Research, Faculty of Food Science and Nutrition, University of Iceland, Reykjavík, Iceland; Unit for Nutrition Research, Landspitali National University Hospital, Reykjavik, Iceland,Univ Iceland, Fac Food Sci & Nutr, Unit Nutr Res, Reykjavik, Iceland.;Landspitali Natl Univ Hosp, Unit Nutr Res, Reykjavik, Iceland4 aut |
700 | 1 | a Thorsdottir, Ingau Unit for Nutrition Research, Faculty of Food Science and Nutrition, University of Iceland, Reykjavík, Iceland; Unit for Nutrition Research, Landspitali National University Hospital, Reykjavik, Iceland,Univ Iceland, Fac Food Sci & Nutr, Unit Nutr Res, Reykjavik, Iceland.;Landspitali Natl Univ Hosp, Unit Nutr Res, Reykjavik, Iceland4 aut |
700 | 1 | a Oresic, Matej,d 1967-u Turku Center for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland; VTT Technical Research Centre of Finland, Espoo, Finland,Univ Turku, Turku Ctr Biotechnol, Turku, Finland.;Abo Akad Univ, Turku, Finland.;VTT Tech Res Ctr Finland, Espoo, Finland4 aut0 (Swepub:oru)moc |
700 | 1 | a Poutanen, Kaisa S.u Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;VTT Tech Res Ctr Finland, Espoo, Finland4 aut |
700 | 1 | a Risérus, Ulf,d 1967-u Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap4 aut0 (Swepub:uu)ulfriser |
700 | 1 | a Åkesson, Björnu Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Skåne University Hospital4 aut0 (Swepub:lu)kc-bak |
700 | 1 | a Dragsted, Lars Oveu Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg,Univ Copenhagen, Dept Nutr Exercise & Sports, Frederiksberg, Denmark4 aut |
710 | 2 | a Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark; Department of Food Science, University of Copenhagen, Frederiksberg, Denmarkb Univ Copenhagen, Dept Nutr Exercise & Sports, Frederiksberg, Denmark.;Univ Copenhagen, Dept Food Sci, Frederiksberg, Denmark4 org |
773 | 0 | t Clinical Nutritiond : Elsevierg 41:2, s. 441-451q 41:2<441-451x 0261-5614x 1532-1983 |
856 | 4 | u https://doi.org/10.1016/j.clnu.2021.12.031y Fulltext |
856 | 4 | u http://www.clinicalnutritionjournal.com/article/S0261561421005963/pdf |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1644714/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1016/j.clnu.2021.12.031x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-96668 |
856 | 4 8 | u https://doi.org/10.1016/j.clnu.2021.12.031 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469771 |
856 | 4 8 | u https://lup.lub.lu.se/record/6bf86c9b-94ac-4a6f-8b58-105864cf0ab4 |
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