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Associations between lactase persistence and the metabolic syndrome in a cross-sectional study in the Canary Islands
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- Almon, Ricardo, 1965- (author)
- Örebro universitet,Institutionen för klinisk medicin,AFC
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- Alvarez-Leon, Eva E. (author)
- Univ Las Palmas Gran Canaria, Fac Hlth Sci, Dept Clin Sci, Canary Isl, Spain; Hosp Insular Gran Canaria, Canarian Hlth Serv, Serv Prevent Med, Canary Isl, Spain
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- Engfeldt, Peter (author)
- Örebro universitet,Institutionen för klinisk medicin,AFC
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- (creator_code:org_t)
- 2009-10-22
- 2009
- English.
- In: European Journal of Nutrition. - Heidelberg, Germany : Springer. - 1436-6207 .- 1436-6215. ; 49:3, s. 141-146
- Journal article (peer-reviewed)
Abstract
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- Background: The single nucleotide polymorphism (SNP) LCT -13910 C>T, associated with genetically determined phenotypes of lactase persistence (LP) or non-persistence (LNP), was studied in relation to the metabolic syndrome (MS).AIim of the study: The aim was to determine if milk intake and MS are associated. We applied Mendelian randomization (MR). The SNP, LCT -13910 C>T, with the genotypes LP (TT/CT) and LNP (CC), was taken as a proxy for milk consumption.Methods: A representative sample of adults belonging to the Canary Islands Nutrition Survey (ENCA) in Spain aged 18-75 years (n = 551) was genotyped for the LCT -13910 C>T polymorphism. We used the International Diabetes Federation (IDF) criteria to define MS. RESULTS: 60% of the population was LP and 40% LNP. One hundred seven LP subjects (35.0%) and 53 LNP subjects (25.6%) showed MS (chi (2) = 5.04, p = 0.025). LP subjects showed a significantly higher odds ratio (OR) for MS than LNP subjects computed for the whole population: both the crude OR (1.56; 95% CI 1.06-2.31) and adjusted OR for sex, age, daily energy intake, physical activity and educational level (1.57; 95% CI 1.02-2.43). Adjusted OR for women with LP was 1.93; 95% CI 1.06-3.52.Conclusions: The T allele of the SNP might constitute a nutrigenetic factor increasing the susceptibility of LP subjects, especially women, to develop MS in the Canary Islands.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- LCT-13910 C > T polymorphism
- Metabolic syndrome
- Metabolic syndrome
- Milk
- Mendelian randomization
- MEDICINE
- MEDICIN
- Physiology
- Fysiologi
- Nutrition
- Näringslära
- Näringslära
- Nutrition
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- ref (subject category)
- art (subject category)
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