The relationship between generalised joint hypermobility and neurodevelopment disorders

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The relationship between generalised joint hypermobility and neurodevelopment disorders

Glans, Martin, 1985- (author): Örebro universitet,Institutionen för medicinska vetenskaper

Bejerot, Susanne, Professor, 1955- (thesis advisor): Örebro universitet,Institutionen för medicinska vetenskaper

Elwin, Marie, PhD, 1953- (thesis advisor): Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län

Baeza-Velasco, Carolina, Docent (opponent): Laboratoire de Psychopathologie et Processus de Santé, Université de Paris, Paris, France

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(creator_code:org_t)

ISBN 9789175294346
Örebro : Örebro University, 2022
English 96 s.
Series: Örebro Studies in Medicine, 1652-4063 ; 260

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Doctoral thesis (other academic/artistic)

Abstract Subject headings

Knowledge about comorbidities is important since they often can affect the diagnoses, treatment and outcome of a patient. Moreover, it may provide an insight to biological underpinnings contributing to the association. Generalised joint hypermobility (GJH) has recently been suggested to be a common, yet unrecognized, comorbidity amongst individuals with NDDs. In the present thesis we aimed to evaluate the relationships between GJH and ADHD and GJH and ASD across the full clinical and non-clinical spectra. Moreover, we aimed to make available a simple screening tool for GJH for Swedish speakers.In study I we translated the five-part questionnaire on hypermobility (5PQ) into Swedish and tested psychometric properties in a non-clinical adult population (n=315). The Swedish 5PQ showed good psychometric properties in the general adult population with a sensitivity of 91%, a specificity of 75%, and an AUC of 0.87. Thus, it is a promising measure for GJH screening in adults. In studies II and III we measured GJH in large cohorts of adults with ADHD (n=431), ASD (n=199) and general population controls (n=419). We evaluated the associations between GJH and ADHD and GJH and ASD by using logistic regression models, while adjusting for age, sex and ethnicity. GJH was associated with ADHD and ASD with adjusted odds ratios of 4.7 and 3.1, respectively.In study IV a large cohort of adults from the general population (n=887) completed a survey form comprising the 5PQ and questions regarding symptoms and traits of ADHD, ASD and motor impairment. Responses were compared between GJH and non-GJH individuals. We found that sub-syndromal neurodevelopmental symptoms were not affected by GJH. Thus, the association between GJH and NDDs appears to be limited to clinical populations. However, the hypothesis needs to be tested with a physical assessment of GJH before any firm conclusions can be drawn.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Attention Deficit Disorder with Hyperactivity (ADHD)
Autism Spectrum Disorder (ASD)
Adults
Biomarkers
Comorbidity
Joint Hypermobility
Joint Instability
Ehlers-Danlos Syndrome
Connective tissue

Publication and Content Type

vet (subject category)
dok (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and General Practice

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