Search: onr:"swepub:oai:DiVA.org:oru-97692" >
Soluble Levels of C...
Soluble Levels of CD163, PD-L1, and IL-10 in Renal Cell Carcinoma Patients
-
- Davidsson, Sabina, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology
-
- Huotilainen, Sofia (author)
- Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
- Carlsson, Jessica, 1984- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology
-
show more...
-
- Sundqvist, Pernilla, 1973- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology
-
show less...
-
(creator_code:org_t)
- 2022-01-28
- 2022
- English.
-
In: Diagnostics. - : MDPI. - 2075-4418. ; 12:2
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://www.mdpi.com...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- CD163+ M2 macrophages have been suggested to counteract tumor immunity by increasing immunosuppressive mechanisms including PD-L1 and IL-10 expression. Soluble levels of PD-L1, IL-10, and CD163 have been reported as potential biomarkers in various cancers, although the prognostic value in renal cell carcinoma (RCC) has to be further elucidated. In the present study, we measured the levels of sPD-L1, sIL-10, and sCD163 in 144 blood samples from patients with RCC. The levels were determined by using enzyme linked immunosorbent assays. Soluble PD-L1 and CD163 were detectable in 100% of the serum samples, and sCD163 in 22% of the urine samples, while only a minority of the samples had detectable sIL-10. Significantly higher serum levels of sPD-L1 and sCD163 were observed in patients with metastatic disease (p < 0.05). The results also showed that patients with high levels of sPD-L1 in serum had shorter cancer-specific survival compared with patients with low levels (p = 0.002). The results indicate that sPD-L1 most significantly reflects tumor progression in RCC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- liquid biopsy
- renal cell carcinoma
- sCD163
- sIL-10
- sPD-L1
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database