Search: onr:"swepub:oai:DiVA.org:oru-97895" > Umbilical cord bloo...
Fältnamn | Indikatorer | Metadata |
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000 | 07261naa a2200553 4500 | |
001 | oai:DiVA.org:oru-97895 | |
003 | SwePub | |
008 | 220309s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-978952 URI |
040 | a (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a vet2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Laajala, Essiu Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland; Turku Doctoral Programme of Molecular Medicine, University of Turku, Turku, Finland; Department of Computer Science, Aalto University, Espoo, Finland4 aut |
245 | 1 0 | a Umbilical cord blood DNA methylation in children who later develop type 1 diabetes |
264 | 1 | b John Wiley & Sons,c 2021 |
338 | a print2 rdacarrier | |
520 | a Distinct DNA methylation patterns have recently been observed to precede Type 1 Diabetes in whole blood collected from young children. Our aim was to determine if such methylation patterns are present already at the time of birth. Reduced representation bisulfite sequencing (RRBS) analysis was performed on a unique collection of umbilical cord blood samples collected within the Type 1 Diabetes Prediction and Prevention (DIPP) study. Children later diagnosed with Type 1 Diabetes and/or testing positive for multiple islet autoantibodies (N=43) were compared to control individuals (N=79), who remained autoantibody‐negative throughout the DIPP follow‐up until 15 years of age. Altogether 24 clinical and technical covariates related to the pregnancy and the mother were included in a binomial mixed effects model, which was fit separately for each high‐coverage CpG site, followed by spatial and multiple testing adjustment of P values. We discovered a strong inflation of P values, which was caused by a standard spatial adjustment method. Findings that were based on Benjamini‐Hochberg corrected spatially adjusted P values, could not be validated by Pyrosequencing. We therefore used permutation‐based significance analysis and showed that sex‐associated differentially methylated cytosines could be reproducibly detected with this approach. After empirical type 1 error control, no differences in cord blood methylation patterns were observed between cases and controls. Differences between children who progress to Type 1 Diabetes and those who remain healthy throughout childhood, are not yet present in the perinatal DNA methylome. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a Autoimmunity | |
653 | a diabetes | |
653 | a molecular immunology | |
700 | 1 | a Ullah, Ubaidu Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 aut |
700 | 1 | a Grönroos, Toniu Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 aut |
700 | 1 | a Rasool, Omidu Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 aut |
700 | 1 | a Aho, Viivi Hallau Department of Computer Science, Aalto University, Espoo, Finland4 aut |
700 | 1 | a Konki, Mikkou Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut |
700 | 1 | a Kattelus, Roosau Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 aut |
700 | 1 | a Mykkänen, Juhau Research Centre of Applied and Preventive Cardiovascular Medicine, Institute of Biomedicine, University of Turku, Turku, Finland4 aut |
700 | 1 | a Nurmio, Mirjau Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland4 aut |
700 | 1 | a Mäkilä, Mari Vahäu Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland4 aut |
700 | 1 | a Kallionpää, Hennau Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut |
700 | 1 | a Lietzén, Niinau Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut |
700 | 1 | a Laiho, Astau Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut |
700 | 1 | a Hyöty, Heikkiu Department of Virology, Faculty of Medicine and Biosciences, University of Tampere, Tampere, Finland4 aut |
700 | 1 | a Elo, Laura L.u Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 aut |
700 | 1 | a Ilonen, Jormau Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland4 aut |
700 | 1 | a Knip, Mikaelu Pediatric Research Center, Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Center for Child Health Research, Tampere University Hospital, Tampere, Finland4 aut |
700 | 1 | a Lund, Riikka J.u Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut |
700 | 1 | a Oresic, Matej,d 1967-u Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut0 (Swepub:oru)moc |
700 | 1 | a Veijola, Riittau Department of Pediatrics, PEDEGO Research Unit, Medical Research Centre, Oulu, Finland4 aut |
700 | 1 | a Lähdesmäki, Harriu Department of Computer Science, Aalto University, Espoo, Finland4 aut |
700 | 1 | a Toppari, Jormau Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland4 aut |
700 | 1 | a Lahesmaa, Riittau Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 aut |
710 | 2 | a Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland; Turku Doctoral Programme of Molecular Medicine, University of Turku, Turku, Finland; Department of Computer Science, Aalto University, Espoo, Finlandb Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 org |
773 | 0 | t European Journal of Immunologyd : John Wiley & Sonsg 51:Suppl. 1, s. 291-291q 51:Suppl. 1<291-291x 0014-2980x 1521-4141 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-97895 |
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