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Pharmacological dif...
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Ekestubbe, LovisaSchool of Medical Sciences, Örebro University, Örebro, Sweden
(author)
Pharmacological differences between beta-blockers and postoperative mortality following colon cancer surgery
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-03-28
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Nature Publishing Group,2022
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-98332
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98332URI
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https://doi.org/10.1038/s41598-022-08736-6DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149172496URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding agency:Örebro University
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β-blocker therapy has been positively associated with improved survival in patients undergoing oncologic colorectal resection. This study investigates if the type of β-blocker used affects 90-day postoperative mortality following colon cancer surgery. The study was designed as a nationwide retrospective cohort study including all adult (≥ 18 years old) patients with ongoing β-blocker therapy who underwent elective and emergency colon cancer surgery in Sweden between January 1, 2007 and December 31, 2017. Patients were divided into four cohorts: metoprolol, atenolol, bisoprolol, and other beta-blockers. The primary outcome of interest was 90-day postoperative mortality. A Poisson regression model with robust standard errors was used, while adjusting for all clinically relevant variables, to determine the association between different β-blockers and 90-day postoperative mortality. A total of 9254 patients were included in the study. There was no clinically significant difference in crude 90-day postoperative mortality rate [n (%)] when comparing the four beta-blocker cohorts metoprolol, atenolol, bisoprolol and other beta-blockers. [97 (1.8%) vs. 28 (2.0%) vs. 29 (1.7%) vs. 11 (1.2%), p = 0.670]. This remained unchanged when adjusting for relevant covariates in the Poisson regression model. Compared to metoprolol, there was no statistically significant decrease in the risk of 90-day postoperative mortality with atenolol [adj. IRR (95% CI): 1.45 (0.89-2.37), p = 0.132], bisoprolol [adj. IRR (95% CI): 1.45 (0.89-2.37), p = 0.132], or other beta-blockers [adj. IRR (95% CI): 0.92 (0.46-1.85), p = 0.825]. In patients undergoing colon cancer surgery, the risk of 90-day postoperative mortality does not differ between the investigated types of β-adrenergic blocking agents.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Bass, Gary Alan,1979-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)gbs
(author)
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Forssten, Maximilian Peter,1996-Örebro universitet,Institutionen för medicinska vetenskaper,Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden(Swepub:oru)mmfn
(author)
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Sjölin, Gabriel,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden(Swepub:oru)glsn
(author)
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Cao, Yang,Associate Professor,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics(Swepub:oru)yco
(author)
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Matthiessen, Peter,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Division of Colorectal Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden(Swepub:oru)pemn
(author)
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Ahl, Rebecka,1987-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Division of Trauma and Emergency Surgery, Department of Surgery, Karolinska University Hospital, Stockholm, Sweden; Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)raal
(author)
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Mohseni, Shahin,1978-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden(Swepub:oru)snmi
(author)
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School of Medical Sciences, Örebro University, Örebro, SwedenInstitutionen för medicinska vetenskaper
(creator_code:org_t)
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In:Scientific Reports: Nature Publishing Group12:12045-2322
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