Search: onr:"swepub:oai:DiVA.org:oru-98332" > Pharmacological dif...
Fältnamn | Indikatorer | Metadata |
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000 | 05225naa a2200433 4500 | |
001 | oai:DiVA.org:oru-98332 | |
003 | SwePub | |
008 | 220330s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:149172496 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-983322 URI |
024 | 7 | a https://doi.org/10.1038/s41598-022-08736-62 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1491724962 URI |
040 | a (SwePub)orud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ekestubbe, Lovisau School of Medical Sciences, Örebro University, Örebro, Sweden4 aut |
245 | 1 0 | a Pharmacological differences between beta-blockers and postoperative mortality following colon cancer surgery |
264 | c 2022-03-28 | |
264 | 1 | b Nature Publishing Group,c 2022 |
338 | a print2 rdacarrier | |
500 | a Funding agency:Örebro University | |
520 | a β-blocker therapy has been positively associated with improved survival in patients undergoing oncologic colorectal resection. This study investigates if the type of β-blocker used affects 90-day postoperative mortality following colon cancer surgery. The study was designed as a nationwide retrospective cohort study including all adult (≥ 18 years old) patients with ongoing β-blocker therapy who underwent elective and emergency colon cancer surgery in Sweden between January 1, 2007 and December 31, 2017. Patients were divided into four cohorts: metoprolol, atenolol, bisoprolol, and other beta-blockers. The primary outcome of interest was 90-day postoperative mortality. A Poisson regression model with robust standard errors was used, while adjusting for all clinically relevant variables, to determine the association between different β-blockers and 90-day postoperative mortality. A total of 9254 patients were included in the study. There was no clinically significant difference in crude 90-day postoperative mortality rate [n (%)] when comparing the four beta-blocker cohorts metoprolol, atenolol, bisoprolol and other beta-blockers. [97 (1.8%) vs. 28 (2.0%) vs. 29 (1.7%) vs. 11 (1.2%), p = 0.670]. This remained unchanged when adjusting for relevant covariates in the Poisson regression model. Compared to metoprolol, there was no statistically significant decrease in the risk of 90-day postoperative mortality with atenolol [adj. IRR (95% CI): 1.45 (0.89-2.37), p = 0.132], bisoprolol [adj. IRR (95% CI): 1.45 (0.89-2.37), p = 0.132], or other beta-blockers [adj. IRR (95% CI): 0.92 (0.46-1.85), p = 0.825]. In patients undergoing colon cancer surgery, the risk of 90-day postoperative mortality does not differ between the investigated types of β-adrenergic blocking agents. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Bass, Gary Alan,d 1979-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)gbs |
700 | 1 | a Forssten, Maximilian Peter,d 1996-u Örebro universitet,Institutionen för medicinska vetenskaper,Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)mmfn |
700 | 1 | a Sjölin, Gabriel,d 1979-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)glsn |
700 | 1 | a Cao, Yang,c Associate Professor,d 1972-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics4 aut0 (Swepub:oru)yco |
700 | 1 | a Matthiessen, Peter,d 1957-u Örebro universitet,Institutionen för medicinska vetenskaper,Division of Colorectal Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)pemn |
700 | 1 | a Ahl, Rebecka,d 1987-u Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Division of Trauma and Emergency Surgery, Department of Surgery, Karolinska University Hospital, Stockholm, Sweden; Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:oru)raal |
700 | 1 | a Mohseni, Shahin,d 1978-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)snmi |
710 | 2 | a School of Medical Sciences, Örebro University, Örebro, Swedenb Institutionen för medicinska vetenskaper4 org |
773 | 0 | t Scientific Reportsd : Nature Publishing Groupg 12:1q 12:1x 2045-2322 |
856 | 4 | u https://doi.org/10.1038/s41598-022-08736-6y Fulltext |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98332 |
856 | 4 8 | u https://doi.org/10.1038/s41598-022-08736-6 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:149172496 |
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