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Comparison of gastr...
Comparison of gastrointestinal side effects from different doses of azithromycin for the treatment of gonorrhoea
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- Ong, Jason J. (author)
- Central Clinical School, Monash University, Melbourne, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
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- Aguirre, Ivette (author)
- Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia
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- Unemo, Magnus, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Institute for Global Health, University College London (UCL), London, UK
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- Kong, Fabian Y. S. (author)
- Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
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- Fairley, Christopher K. (author)
- Central Clinical School, Monash University, Melbourne, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia
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- Hocking, Jane S. (author)
- Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
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- Chow, Eric P. F. (author)
- Central Clinical School, Monash University, Melbourne, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia; Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
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- Tieosapjaroen, Warittha (author)
- Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia
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- Ly, Jenny (author)
- Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia
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- Chen, Marcus Y. (author)
- Central Clinical School, Monash University, Melbourne, Australia; Melbourne Sexual Health Centre, Alfred Hospital, Melbourne, Australia
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(creator_code:org_t)
- 2022-04-13
- 2022
- English.
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In: Journal of Antimicrobial Chemotherapy. - : Oxford University Press. - 0305-7453 .- 1460-2091. ; 77:7, s. 2011-2016
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- OBJECTIVES: Azithromycin is commonly used to treat Neisseria gonorrhoeae. We compared its gastrointestinal side effects using 1 g single, 2 g single or 2 g split (i.e. 1 g plus 1 g 6-12 h later) dosing, representing our clinic's changing guidelines over the study period.METHODS: We recruited consecutive sexual health clinic patients who received azithromycin (and 500 mg ceftriaxone) for uncomplicated gonorrhoea. Each patient received a text message 48 h after their attendance to complete a questionnaire.RESULTS: Patients received 1 g single (n = 271), 2 g single (218) or 2 g split (105) doses. Vomiting was less common for 1 g versus 2 g single dose [1.1% versus 3.7%; risk difference (RD): -2.6%; 95% CI: -0.2 to -5.4] and 2 g split versus 2 g single dose (0.9% versus 3.7%; RD: -2.8%; 95% CI: -0.3 to -5.8). Nausea was less common for 1 g versus 2 g single dose (13.7% versus 43.1%; RD: -29.5%; 95% CI: -21.7 to -37.2) and 2 g split versus 2 g single dose (16.4% versus 43.1%; RD: -26.8; 95% CI: -17.2 to -36.3). Diarrhoea was less common for 1 g versus 2 g single dose (25.5% versus 50.9%; RD: -25.5%; 95% CI: -17.0 to -33.9) and 2 g split versus 2 g single dose (30.9% versus 50.9%; RD: -20.0; 95% CI: -9.1 to -30.9). Almost all were willing to retake the same dosing for gonorrhoea in the future: 97% for 1 g single; 94% for 2 g single; and 97% for 2 g split dose.CONCLUSIONS: Azithromycin 2 g split dose for gonorrhoea resulted in significantly less vomiting, nausea and diarrhoea than a 2 g single dose.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Ong, Jason J.
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Aguirre, Ivette
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Unemo, Magnus, 1 ...
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Kong, Fabian Y. ...
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Fairley, Christo ...
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Hocking, Jane S.
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Chow, Eric P. F.
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Tieosapjaroen, W ...
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Ly, Jenny
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Chen, Marcus Y.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Journal of Antim ...
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Örebro University