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  • Madjedi, Kian M.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK; Department of Ophthalmology, University of Calgary, Alberta, Canada (author)

The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier,2022
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:oru-98848
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98848URI
  • https://doi.org/10.1016/j.ophtha.2022.04.023DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:UCL Overseas Research ScholarshipFight for Sight, London, United Kingdom 1956ADesmond FoundationNovartisUnited Kingdom Research and Innovation Future Leaders FellowshipMoorfields Eye Charity (Springboard Award)Career Development FellowshipUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Eye Institute (NEI) EY015473 EY032559 Research to Prevent Blindness (RPB)The Glaucoma Foundation, New York, New YorkBoehringer IngelheimRoche DiagnosticsAssociation for Research in Vision and Ophthalmology Foundation (David Epstein AwardUK Research and Innovation Future Leaders Fellowship (Medical Research Council MR/T040912/1United Kingdom Department of HealthNational Institute for Health Research (NIEye Hospital NHS Foundation TrustUCL Institute of Ophthalmology for a Biomedical Research Centre for OphthalmologyMoorfields Eye CharityNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation TrustUCL Institute of OphthalmologyInternational Glaucoma Association (United Kingdom)UK Research & Innovation (UKRI)Medical Research Council UK (MRC) SP2024/0201  MR/N003284/1  Cancer Research UK G9502233  C864/A8257 
  • PURPOSE: Serum lipids are modifiable, routinely collected blood tests associated with cardiovascular health. We examined the association of commonly collected serum lipid measures (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL-C) and triglycerides (TG)) with intraocular pressure (IOP).DESIGN: Cross-sectional study in the UK Biobank and EPIC-Norfolk cohorts.PARTICIPANTS: We included 94 323 participants of UK Biobank (mean age 57 years) and 6 230 participants of EPIC-Norfolk (mean age 68 years) with data on TC, HDL-C, LDL-C, TG collected between 2006-2009.METHODS: Multivariable linear regression adjusting for demographic, lifestyle, anthropometric, medical and ophthalmic covariables was used to examine the associations of serum lipids with IOPcc.MAIN OUTCOME MEASURES: IOPcc.RESULTS: Higher levels of TC, HDL-C and LDL-C were independently associated with higher IOPcc in both cohorts after adjustment for key demographic, medical and lifestyle factors. For each standard deviation increase in TC, HDL-C, and LDL-C, IOPcc (mmHg) was higher by 0.09 (95% CI: 0.06-0.11; P<0.001), 0.11 (95% CI 0.08-0.13; P<0.001), 0.07 (95% CI: 0.05-0.09, P<0.001), respectively in the UK Biobank cohort. In the EPIC-Norfolk cohort, each additional standard deviation in TC, HDL-C, and LDL-C was associated with a higher IOPcc (mmHg) by 0.19 (95% CI 0.07-0.31, P=0.001), 0.14 (95% CI 0.03-0.25, P=0.016), and 0.17 (95% CI 0.06-0.29, P=0.003). An inverse association between TGs and IOP in the UK Biobank (-0.05, 95% CI -0.08 to -0.03, P<0.001) was not replicated in the EPIC cohort (P=0.30).CONCLUSION: Our findings suggest that serum TC, HDL-C and LDL-C are positively associated with IOP in two UK cohorts and TGs may be negatively associated. Future research is required to assess whether these associations are causal in nature.

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  • Stuart, Kelsey V.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK (author)
  • Chua, Sharon Y. L.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK (author)
  • Luben, Robert N.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK (author)
  • Warwick, AlasdairUCL Institute of Cardiovascular Science, London, United Kingdom (author)
  • Pasquale, Louis R.Icahn School of Medicine at Mount Sinai, Department of Ophthalmology, New York, NY, USA (author)
  • Kang, Jae H.Brigham and Women's Hospital / Harvard Medical School, Boston, MA, USA (author)
  • Wiggs, Janey L.Department of Ophthalmology, Harvard Medical School, Boston, MA, USA (author)
  • Lentjes, Marleen,1974-Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics; Nutrient Gut-Brain Interaction(Swepub:oru)mals (author)
  • Aschard, HuguesInstitute Pasteur, Paris, France (author)
  • Sattar, NaveedBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK (author)
  • Foster, Paul J.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK (author)
  • Khawaja, Anthony P.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK (author)
  • Modifiable Risk Factors for Glaucoma Collaboration and the UK Biobank Eye and Vision Consortium, - (contributor)
  • NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK; Department of Ophthalmology, University of Calgary, Alberta, CanadaNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK (creator_code:org_t)

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  • In:Ophthalmology: Elsevier129:9, s. 986-9960161-64201549-4713

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