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Shrestha, Sarita,1991-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK; Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University Hospital, Örebro, Sweden
(author)
Association between inflammatory bowel disease and spondyloarthritis : findings from a nationwide study in Sweden
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-05-05
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Oxford University Press,2022
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-98862
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98862URI
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https://doi.org/10.1093/ecco-jcc/jjac065DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:150031300URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201715URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding agency:Orebro University Hospital Research Foundation OLL-936004 OLL-890291 OLL-790011 OLL-723021
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BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) has been associated with spondyloarthritis (SpA), but population-based estimates are scarce. Here we compare the occurrence of SpA before and after a diagnosis of IBD to the general population, overall and by IBD subtype and age.METHODS: We used a nationwide register-based cohort study of 39,203 patients diagnosed with IBD during 2006-2016, identified from Swedish registers and gastrointestinal biopsy data, and 390,490 matched reference individuals from the general population. Conditional logistic regression models were used to estimate odds ratios (ORs) for a prior (prevalent) SpA diagnosis and conditional Cox regression to calculate hazard ratios (HRs) for a subsequent (incident) SpA diagnosis in IBD patients.RESULTS: IBD patients were more likely to have prevalent SpA at IBD diagnosis (2.5%) compared to reference individuals (0.7%) with an OR of 3.48 (95%CI:3.23-3.75). They also more often received an incident diagnosis of SpA; during 23,341,934 person-years of follow-up in IBD patients, there were 1,030 SpA events (5.0/1,000 person-years) compared to 1,524 SpA events in the reference group (0.72/1,000 person-years), corresponding to an HR of 7.15 (95%CI:6.60-7.75). In subgroup analyses, associations were most pronounced among patients with Crohn's disease [(OR=5.20; 95%CI:4.59-5.89), and (HR=10.55; 95%CI:9.16-12.15)] and paediatric onset IBD [(OR=3.63; 95%CI:2.35-5.59) and (HR=15.03; 95%CI:11.01-20.53)].CONCLUSION: IBD patients more frequently experience SpA both before and after the diagnosis of IBD compared to the general population, supporting evidence of a shared pathophysiology. The variation in SpA comorbidity across IBD subtypes and age-groups, calls for targeted approaches to facilitate timely diagnosis and intervention.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Brand, Judith S.Population Health Sciences, Bristol Medical School, Bristol, United Kingdom; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University Hospital, Örebro, Sweden,Clinical Epidemiology and Biostatistics
(author)
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Järås, JacobKarolinska Institutet,Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
(author)
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Schoultz, Ida,1979-Örebro universitet,Institutionen för medicinska vetenskaper,School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)isz
(author)
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Montgomery, Scott,1961-Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, United Kingdom,Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University Hospital, Örebro, Sweden; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, UK(Swepub:oru)smy
(author)
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Askling, JohanClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Rheumatology, Theme Inflammation and Ageing, Karolinska University Hospital, Stockholm, Sweden
(author)
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Ludvigsson, Jonas F.,1969-Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA(Swepub:oru)jsln
(author)
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Olen, OlaKarolinska Institutet,Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Sachs’ Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden
(author)
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Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)jshn
(author)
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SWIBREG Study Group, -
(contributor)
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Myrelid, Pär,1970-Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,SWIBREG Study Group(Swepub:liu)parmy24
(contributor)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
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In:Journal of Crohn's & Colitis: Oxford University Press16:1, s. 1540-15501873-99461876-44791197-4982
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