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Umbilical cord bloo...
Umbilical cord blood DNA methylation in children who later develop type 1 diabetes
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- Laajala, Essi (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Turku Doctoral Programme of Molecular Medicine, University of Turku, Turku, Finland; Department of Computer Science, Aalto University, Espoo, Finland
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- Kalim, Ubaid Ullah (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland
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- Grönroos, Toni (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland
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- Rasool, Omid (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland
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- Halla-Aho, Viivi (author)
- Department of Computer Science, Aalto University, Espoo, Finland
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- Konki, Mikko (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Kattelus, Roosa (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland
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- Mykkänen, Juha (author)
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland
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- Nurmio, Mirja (author)
- Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
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- Vähä-Mäkilä, Mari (author)
- Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
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- Kallionpää, Henna (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Lietzén, Niina (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Ghimire, Bishwa R. (author)
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
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- Laiho, Asta (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland
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- Hyöty, Heikki (author)
- Department of Virology, Faculty of Medicine and Biosciences, University of Tampere, Tampere, Finland
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- Elo, Laura L. (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Institute of Biomedicine, University of Turku, Turku, Finland
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- Ilonen, Jorma (author)
- Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland
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- Knip, Mikael (author)
- Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Center for Child Health Research, Tampere University Hospital, Tampere, Finland
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- Lund, Riikka J. (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland
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- Veijola, Riitta (author)
- Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
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- Lähdesmäki, Harri (author)
- Department of Computer Science, Aalto University, Espoo, Finland
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- Toppari, Jorma (author)
- Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland
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- Lahesmaa, Riitta (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Institute of Biomedicine, University of Turku, Turku, Finland
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(creator_code:org_t)
- 2022-06-18
- 2022
- English.
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In: Diabetologia. - : Springer. - 0012-186X .- 1432-0428. ; 65:9, s. 1534-1540
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- AIMS/HYPOTHESIS: Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated with later progression to type 1 diabetes.METHODS: Reduced representation bisulphite sequencing (RRBS) analysis was performed on umbilical cord blood samples collected within the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study. Children later diagnosed with type 1 diabetes and/or who tested positive for multiple islet autoantibodies (n = 43) were compared with control individuals (n = 79) who remained autoantibody-negative throughout the DIPP follow-up until 15 years of age. Potential confounding factors related to the pregnancy and the mother were included in the analysis.RESULTS: No differences in the umbilical cord blood methylation patterns were observed between the cases and controls at a false discovery rate <0.05.CONCLUSIONS/INTERPRETATION: Based on our results, differences between children who progress to type 1 diabetes and those who remain healthy throughout childhood are not yet present in the perinatal DNA methylome. However, we cannot exclude the possibility that such differences would be found in a larger dataset.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Bisulphite sequencing
- DNA methylation
- Epigenomics
- Follow-up study
- Type 1 diabetes
- Umbilical cord blood
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Laajala, Essi
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Kalim, Ubaid Ull ...
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Grönroos, Toni
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Rasool, Omid
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Halla-Aho, Viivi
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Konki, Mikko
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Kattelus, Roosa
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Mykkänen, Juha
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Nurmio, Mirja
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Vähä-Mäkilä, Mar ...
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Kallionpää, Henn ...
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Lietzén, Niina
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Ghimire, Bishwa ...
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Laiho, Asta
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Hyöty, Heikki
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Elo, Laura L.
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Ilonen, Jorma
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Knip, Mikael
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Lund, Riikka J.
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Oresic, Matej, 1 ...
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Veijola, Riitta
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Lähdesmäki, Harr ...
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Toppari, Jorma
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Lahesmaa, Riitta
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetologia
- By the university
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Örebro University