Cardiovascular risk factors in attention-deficit/hyperactivity disorder: A family design study of Swedish conscripts

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Garcia-Argibay, Miguel,1988-Örebro University,Karolinska Institute,Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (author)

Cardiovascular risk factors in attention-deficit/hyperactivity disorder : A family design study of Swedish conscripts

Article/chapterEnglish2022

Publisher, publication year, extent ...

2022-06-29
John Wiley & Sons,2022
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:oru-99827
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-99827URI
https://doi.org/10.1002/mpr.1930DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:150097130URI
https://lup.lub.lu.se/record/60faa0b7-e564-4bf4-885d-6a508ef84aa6URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Objective: (1) investigate the associations of attention-deficit/hyperactivity disorder (ADHD) with systolic and diastolic blood pressure, resting heart rate, pulse pressure (PP), physical fitness, and BMI; (2) explore whether cardiovascular risk factors and ADHD share genetic and environmental influences; (3) assess if pharmacological treatment for ADHD influences these associations.Methods: We identified 395,978 individuals born between 1973 and 1991 who had military conscription examinations at a mean age of 18.3 years (SD = 0.57) and their full-siblings within the same cohort (N = 208,060) by linking population-based registers in Sweden. Results Significantly increased risk of ADHD was observed in individuals with low systolic blood pressure (SBP) and PP, low physical fitness, and in those who had overweight or obesity after adjustments (adjusted Odds Ratio [OR] ranging from 1.10 to 1.45). Full siblings of individuals with low SBP, low physical fitness, and obesity were more likely to receive an ADHD diagnosis compared to full siblings without those risk factors (OR ranging from 1.17 to 1.31). Additionally, analyses showed robust associations between ADHD and low SBP, low physical fitness, and obesity, even in ADHD medication-naïve individuals.Conclusions: Individuals with several cardiovascular risk factors are more often diagnosed with ADHD, regardless of psychiatric comorbidity. These association are not explained by ADHD pharmacotherapy, rather, they are in part due to shared familial risk factors.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Allmänmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine General Practice hsv//eng
Attention deficit hyperactivity disorder
blood pressure
cardiovascular risk factors
physical fitness
resting heart rate
Psychiatry
Psykiatri
Medicine
Medicin
attention deficit hyperactivity disorder
blood pressure
cardiovascular risk factors
physical fitness
resting heart rate

Added entries (persons, corporate bodies, meetings, titles ...)

Du Rietz, EbbaKarolinska Institute,Karolinska Institutet (author)
Hartman, Catharina A.Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands (author)
Lichtenstein, PaulKarolinska Institute,Karolinska Institutet (author)
Chang, ZhengKarolinska Institute,Karolinska Institutet (author)
Fava, CristianoLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,University of Verona(Swepub:lu)endo-cfa (author)
Cortese, SamueleSchool of Psychology, University of Southampton, Southampton, UK; Faculty of Medicine, Clinical and Experimental Science (CNS and Psychiatry), University of Southampton, Southampton, Hampshire, UK. 8 Solent NHS Trust, Southampton, UK; Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York City, New York, USA; School of Medicine, Division of Psychiatry and Applied Psychology, University of Nottingham, Nottingham, UK (author)
Larsson, Henrik,1975-Örebro University,Karolinska Institute,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln (author)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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In:International Journal of Methods in Psychiatric Research: John Wiley & Sons31:41049-89311557-0657

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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