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Individualization o...
Individualization of levodopa treatment using a microtablet dispenser and ambulatory accelerometry
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- Johansson, Dongni, 1988 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Ericsson, Anders (author)
- RISE,Acreo
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- Johansson, Anders (author)
- Karolinska Institutet
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- Medvedev, Alexander (author)
- Uppsala universitet,Avdelningen för systemteknik,Reglerteknik
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- Nyholm, Dag (author)
- Uppsala universitet,Neurologi
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- Ohlsson, Fredrik (author)
- RISE,Acreo
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- Senek, Marina (author)
- Uppsala universitet,Neurologi
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- Spira, Jack (author)
- Sensidose AB, Sweden
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- Thomas, Ilias (author)
- Högskolan Dalarna,Mikrodataanalys
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- Westin, Jerker (author)
- Högskolan Dalarna,Datateknik
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- Bergquist, Fredrik (author)
- University of Gothenburg, Sweden
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- Bergquist, Filip, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology,Institute of Neuroscience and Physiology, Department of Pharmacology
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(creator_code:org_t)
- 2018-01-25
- 2018
- English.
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In: CNS Neuroscience & Therapeutics. - : Wiley. - 1755-5930 .- 1755-5949. ; 24:5, s. 439-447
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Abstract
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- Aim: This 4-week open-label observational study describes the effect of introducing a microtablet dose dispenser and adjusting doses based on objective free-living motor symptom monitoring in individuals with Parkinson's disease (PD). Methods: Twenty-eight outpatients with PD on stable levodopa treatment with dose intervals of ≤4 hour had their daytime doses of levodopa replaced with levodopa/carbidopa microtablets, 5/1.25 mg (LC-5) delivered from a dose dispenser device with programmable reminders. After 2 weeks, doses were adjusted based on ambulatory accelerometry and clinical monitoring. Results: Twenty-four participants completed the study per protocol. The daily levodopa dose was increased by 15% (112 mg, P < 0.001) from period 1 to 2, and the dose interval was reduced by 12% (22 minutes, P = 0.003). The treatment adherence to LC-5 was high in both periods. The MDS-UPDRS parts II and III, disease-specific quality of life (PDQ-8), wearing-off symptoms (WOQ-19), and nonmotor symptoms (NMS Quest) improved after dose titration, but the generic quality-of-life measure EQ-5D-5L did not. Blinded expert evaluation of accelerometry results demonstrated improvement in 60% of subjects and worsening in 25%. Conclusions: The introduction of a levodopa microtablet dispenser and accelerometry aided dose adjustments improve PD symptoms and quality of life in the short term.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik -- Reglerteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering -- Control Engineering (hsv//eng)
Keyword
- Accelerometry
- Dose titration
- Microtablets
- Observational study
- Parkinson's disease
- Complex Systems – Microdata Analysis
- accelerometry
- dose titration
- microtablets
- observational study
- Parkinson's disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Johansson, Dongn ...
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Ericsson, Anders
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Johansson, Ander ...
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Medvedev, Alexan ...
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Nyholm, Dag
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Ohlsson, Fredrik
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Senek, Marina
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Spira, Jack
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Thomas, Ilias
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Westin, Jerker
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Bergquist, Fredr ...
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Bergquist, Filip ...
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Electrical Engin ...
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and Control Engineer ...
- Articles in the publication
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CNS Neuroscience ...
- By the university
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RISE
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Högskolan Dalarna
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Uppsala University
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Karolinska Institutet
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University of Gothenburg