Search: onr:"swepub:oai:DiVA.org:ri-37820" > Antibiotic-Free Cat...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03921naa a2200565 4500 | |
001 | oai:DiVA.org:ri-37820 | |
003 | SwePub | |
008 | 190301s2019 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:kth-249169 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-378202 URI |
024 | 7 | a https://doi.org/10.1002/adhm.2018016192 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2491692 URI |
040 | a (SwePub)rid (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Andrén, Oliver C. J.u KTH,Ytbehandlingsteknik4 aut0 (Swepub:kth)u1fshusr |
245 | 1 0 | a Antibiotic-Free Cationic Dendritic Hydrogels as Surgical-Site-Infection-Inhibiting Coatings |
264 | c 2019-02-08 | |
264 | 1 | b Wiley,c 2019 |
338 | a electronic2 rdacarrier | |
500 | a QC 20190412 | |
520 | a A non-toxic hydrolytically fast-degradable antibacterial hydrogel is herein presented to preemptively treat surgical site infections during the first crucial 24 h period without relying on conventional antibiotics. The approach capitalizes on a two-component system that form antibacterial hydrogels within 1 min and consist of i) an amine functional linear-dendritic hybrid based on linear poly(ethylene glycol) and dendritic 2,2-bis(hydroxymethyl)propionic acid, and ii) a di-N-hydroxysuccinimide functional poly(ethylene glycol) cross-linker. Broad spectrum antibacterial effect is achieved by multivalent representation of catatonically charged β-alanine on the dendritic periphery of the linear dendritic component. The hydrogels can be applied readily in an in vivo setting using a two-component syringe delivery system and the mechanical properties can accurately be tuned in the range equivalent to fat tissue and cartilage (G' = 0.5-8 kPa). The antibacterial effect is demonstrated both in vitro toward a range of relevant bacterial strains and in an in vivo mouse model of surgical site infection. | |
650 | 7 | a NATURVETENSKAPx Kemix Polymerkemi0 (SwePub)104062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Polymer Chemistry0 (SwePub)104062 hsv//eng |
653 | a antibacterial | |
653 | a dendrimer | |
653 | a hydrogels | |
653 | a surgical-site infection | |
700 | 1 | a Ingverud, Tobias,d 1989-u KTH,Ytbehandlingsteknik4 aut0 (Swepub:kth)u1fsrafk |
700 | 1 | a Hult, Daniel,d 1986-u KTH,Ytbehandlingsteknik4 aut0 (Swepub:kth)u1jscf5u |
700 | 1 | a Håkansson, Joakimu RISE,Kemi och material4 aut0 (Swepub:ri)JoakimHa@ri.se |
700 | 1 | a Bogestål, Yaldau RISE,Kemi och material4 aut |
700 | 1 | a Caous, Josefin Su RISE,Kemi och material,Metodik för produktframtagning4 aut0 (Swepub:ri)josefinca@ri.se |
700 | 1 | a Blom, Kristinau Medibiome AB, Sweden4 aut |
700 | 1 | a Zhang, Yuningu KTH,Fiber- och polymerteknologi4 aut0 (Swepub:kth)u1bh78yi |
700 | 1 | a Andersson, Thereseu RISE,Kemi och material4 aut0 (Swepub:ri)theresean@ri.se |
700 | 1 | a Pedersen, Emmau RISE,Kemi och material4 aut0 (Swepub:ri)emma.pedersen@ri.se |
700 | 1 | a Björn, Camillau RISE,Kemi och material4 aut0 (Swepub:ri)CamillaBj@ri.se |
700 | 1 | a Löwenhielm, Peteru RISE,Kemi och material4 aut |
700 | 1 | a Malkoch, Michael,d 1974-u KTH,Ytbehandlingsteknik4 aut0 (Swepub:kth)u18z6ljf |
710 | 2 | a KTHb Ytbehandlingsteknik4 org |
773 | 0 | t Advanced Healthcare Materialsd : Wileyx 2192-2640x 2192-2659 |
856 | 4 | u https://ri.diva-portal.org/smash/get/diva2:1292975/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.201801619 |
856 | 4 | u https://doi.org/10.1002/adhm.201801619y Publisher |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-37820 |
856 | 4 8 | u https://doi.org/10.1002/adhm.201801619 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-249169 |
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