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  • Assenhöj, MariaLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Arbets- och miljömedicin (author)

Protein interaction, monocyte toxicity and immunogenic properties of cerium oxide crystals with 5% or 14% gadolinium, cobalt oxide and iron oxide nanoparticles–an interdisciplinary approach

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-09-01
  • Taylor and Francis Ltd.2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:ri-56716
  • https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-56716URI
  • https://doi.org/10.1080/17435390.2021.1966115DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-179165URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Region Ostergotland ALF [LIO-606891]; AFA insurances [150246]; Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University [2009-00971]; Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundation [2012.0083 CTS, 18:399]; Center in Nano Science and Nano technology at LiTH (CeNano) at Linkoping University
  • Metal oxide nanoparticles are widely used in both consumer products and medical applications, but the knowledge regarding exposure-related health effects is limited. However, it is challenging to investigate nanoparticle interaction processes with biological systems. The overall aim of this project was to improve the possibility to predict exposure-related health effects of metal oxide nanoparticles through interdisciplinary collaboration by combining workflows from the pharmaceutical industry, nanomaterial sciences, and occupational medicine. Specific aims were to investigate nanoparticle-protein interactions and possible adverse immune reactions. Four different metal oxide nanoparticles; CeOx nanocrystals with 5% or 14% Gd, Co3O4, and Fe2O3, were characterized by dynamic light scattering and high-resolution transmission electron microscopy. Nanoparticle-binding proteins were identified and screened for HLA-binding peptides in silico. Monocyte interaction with nanoparticle–protein complexes was assessed in vitro. Herein, for the first time, immunogenic properties of nanoparticle-binding proteins have been characterized. The present study indicates that especially Co3O4-protein complexes can induce both ‘danger signals’, verified by the production of inflammatory cytokines and simultaneously bind autologous proteins, which can be presented as immunogenic epitopes by MHC class II. The clinical relevance of these findings should be further evaluated to investigate the role of metal oxide nanoparticles in the development of autoimmune disease. The general workflow identified experimental difficulties, such as nanoparticle aggregate formation and a lack of protein-free buffers suitable for particle characterization, protein analyses, as well as for cell studies. This confirms the importance of future interdisciplinary collaborations. © 2021 The Author(s). 

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Eriksson, PeterLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)peter35 (author)
  • Dönnes, PierreSciCross AB, Sweden (author)
  • Ljunggren, StefanLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Arbets- och miljömedicin(Swepub:liu)stelj68 (author)
  • Marcusson-Ståhl, MarithaRISE,Kemiska processer och läkemedel,Res Inst Sweden RISE, Sweden (author)
  • Du Rietz, AnnaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)anndu45 (author)
  • Uvdal, KajsaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)kajuv09 (author)
  • Karlsson, HannaLinköping University, Sweden (author)
  • Cederbrant, KarinRISE,Res Inst Sweden RISE, Sweden (author)
  • Karlsson, HelenLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Arbets- och miljömedicin(Swepub:liu)helka90 (author)
  • Linköpings universitetAvdelningen för prevention, rehabilitering och nära vård (creator_code:org_t)

Related titles

  • In:Nanotoxicology: Taylor and Francis Ltd.15:8, s. 1035-10381743-53901743-5404

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