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Oxygenated Nanocell...
Oxygenated Nanocellulose - A Material Platform for Antibacterial Wound Dressing Devices
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- Knutsen, Maja (author)
- Oxy Solutions, Norway
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- Agrenius, Karin (author)
- RISE,Metodik för produktframtagning
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Ugland, Hege (author)
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- Petronis, Sarunas (author)
- RISE,Metodik för produktframtagning
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- Haglerod, Camilla (author)
- Oxy Solutions, Norway
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- Håkansson, Joakim (author)
- Göteborgs universitet,RISE,Metodik för produktframtagning,Gothenburg University, Sweden,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Chinga-Carrasco, Gary (author)
- RISE,Material- och ytdesign
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(creator_code:org_t)
- 2021-09-30
- 2021
- English.
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In: ACS Applied Bio Materials. - : American Chemical Society. - 2576-6422. ; 4:10, s. 7554-7562
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Both carboxylated cellulose nanofibrils (CNF) and dissolved oxygen (DO) have been reported to possess antibacterial properties. However, the combination for use as wound dressings against biofilm infections in chronic wounds is less known. The present study reports the development of oxygenated CNF dispersions that exhibit strong antibacterial effect. Carboxylated CNF dispersions with different oxidation levels were oxygenated by the OXY BIO System and tested for antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus. The results reveal that the higher oxidation level of the CNFs, the better antibacterial effect. Scanning electron microscopy of bacterial biofilms revealed that a potential mechanism of action of the CNFs is the formation of a network surrounding and entrapping the bacteria. This effect is further potentiated by the oxygenation process. A CNF sample (concentration 0.6 wt %) that was oxygenated to a DO level of 46.4 mg/L demonstrated a strong antibacterial effect against S. aureus in vivo using a mouse model of surgical site infection. The oxygenated CNF dispersion reduced the bacterial survival by 71%, after 24 h treatment. The potent antibacterial effect indicates that oxygenated nanocellulose is a promising material for antibacterial wound dressings. © 2021 The Authors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Keyword
- antibacterial properties
- biofilm infections
- hyperoxia
- nanocellulose
- topical dressings
- wound healing
- Biofilms
- Dispersions
- Dissolved oxygen
- Scanning electron microscopy
- Antibacterial effects
- Antibacterials
- Cellulose nanofibrils
- Nano-cellulose
- Topical dressing
- Wound dressings
- Bacteria
- Diseases
- Formation
- Oxidation
- Processes
- Surgical Dressings
- Survival
- wound healing
- topical dressings
- nanocellulose
- antibacterial
- properties
- hyperoxia
- biofilm infections
- nanofibrillar cellulose
- model
- therapy
- hydrogels
- efficacy
- hypoxia
- Science & Technology - Other Topics
- Materials Science
Publication and Content Type
- ref (subject category)
- art (subject category)
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