Personalized tissue-engineered arteries as vascular graft transplants: A safety study in sheep

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Personalized tissue-engineered arteries as vascular graft transplants : A safety study in sheep

Jenndahl, L. (author): VERIGRAFT AB, Sweden

Österberg, Klas, 1966 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine

Bogestål, Yalda (author): RISE,Metodik för produktframtagning

Simsa, R. (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

Gustafsson-Hedberg, T. (author): VERIGRAFT AB, Sweden

Stenlund, Patrik (author): RISE,Metodik för produktframtagning

Petronis, Sarunas (author): RISE,Metodik för produktframtagning

Krona, Annika (author): RISE,Jordbruk och livsmedel

Fogelstrand, Per, 1971 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

Strehl, R. (author): VERIGRAFT AB, Sweden

Håkansson, Joakim (author): Gothenburg University,Göteborgs universitet,RISE,Metodik för produktframtagning,University of Gothenburg, Sweden,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine

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Japanese Society of Regenerative Medicine, 2022
2022
English.
In: Regenerative Therapy. - : Japanese Society of Regenerative Medicine. - 2352-3204. ; 21, s. 331-341

Related links:: https://doi.org/10.1...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; https://gup.ub.gu.se...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Patients with cardiovascular disease often need replacement or bypass of a diseased blood vessel. With disadvantages of both autologous blood vessels and synthetic grafts, tissue engineering is emerging as a promising alternative of advanced therapy medicinal products for individualized blood vessels. By reconditioning of a decellularized blood vessel with the recipient's own peripheral blood, we have been able to prevent rejection without using immunosuppressants and prime grafts for efficient recellularization in vivo. Recently, decellularized veins reconditioned with autologous peripheral blood were shown to be safe and functional in a porcine in vivo study as a potential alternative for vein grafting. In this study, personalized tissue engineered arteries (P-TEA) were developed using the same methodology and evaluated for safety in a sheep in vivo model of carotid artery transplantation. Five personalized arteries were transplanted to carotid arteries and analyzed for safety and patency as well as with histology after four months in vivo. All grafts were fully patent without any occlusion or stenosis. The tissue was well cellularized with a continuous endothelial cell layer covering the luminal surface, revascularized adventitia with capillaries and no sign of rejection or infection. In summary, the results indicate that P-TEA is safe to use and has potential as clinical grafts.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)

Keyword

ATMP
Blood vessels
Recellularization
Regenerative medicine
Scaffold
Tissue engineering
amoxicillin
attane
buprenorphine
carprofen
clopidogrel
dalteparin
dexmedetomidine
heparin
isoflurane
norocarp
poliglecaprone
promea
propofol
receptor type tyrosine protein phosphatase C
vetergesic
vetrimoxin
adventitia
anatomical concepts
angiography
animal experiment
animal model
animal tissue
antibiotic prophylaxis
arterial stiffness
artery anastomosis
artery transplantation
Article
biomechanics
biopsy technique
blood flow
blood vessel graft
blood vessel parameters
blood vessel wall
burst pressure
capillary
carotid artery transplantation
confocal laser scanning microscopy
controlled study
decellularization
decellularized blood vessel
device safety
DNA extraction
end to end anastomosis
endothelial cell layer
evening dosage
extracellular matrix
failure strain
female
fluorescence microscopy
full luminal endothelialization
histology
hyperplasia
immunohistochemistry
intimal hyperplasia
luminal surface
medical procedures
morning dosage
nonhuman
reconditioning of vascular graft
revascularization
scanning electron microscopy
ATMP
Blood vessels
Recellularization
Regenerative medicine
Scaffold
Tissue engineering
amoxicillin
attane
buprenorphine
carprofen
clopidogrel
dalteparin
dexmedetomidine
heparin
isoflurane
norocarp
poliglecaprone
promea
propofol
receptor type tyrosine protein phosphatase C
vetergesic
vetrimoxin
adventitia
anatomical concepts
angiography
animal experiment
animal model
animal tissue
antibiotic prophylaxis
arterial stiffness
artery anastomosis
artery transplantation
Article
biomechanics
biopsy technique
blood flow
blood vessel graft
blood vessel parameters
blood vessel wall
burst pressure
capillary
carotid artery transplantation
confocal laser scanning microscopy
controlled study
decellularization
decellularized blood vessel
device safety
DNA extraction
end to end anastomosis
endothelial cell layer
evening dosage
extracellular matrix
failure strain
female
fluorescence microscopy
full luminal endothelialization
histology
hyperplasia
immunohistochemistry
intimal hyperplasia
luminal surface
medical procedures
morning dosage
nonhuman
reconditioning of vascular graft
revascularization
scanning electron microscopy

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ref (subject category)
art (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

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By the university: RISE; University of Gothenburg

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