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Flexible Organic El...
Flexible Organic Electronic Ion Pump Fabricated Using Inkjet Printing and Microfabrication for Precision In Vitro Delivery of Bupivacaine
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- Cherian, Dennis, 1989- (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Linköping University, Sweden
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- Roy, Arghyamalya, 1992- (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Linköping University, Sweden
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- Bersellini Farinotti, Alex (author)
- Karolinska Institutet,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Abrahamsson, Tobias, 1991- (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Linköping University, Sweden
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- Arbring Sjöström, Theresia, 1987- (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Linköping University, Sweden
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- Tybrandt, Klas, 1982- (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Linköping University, Sweden
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- Nilsson, David (author)
- RISE,Smart hårdvara,Unit of Printed Electronics, RISE Research Institutes of Sweden, Norrköping, Sweden
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- Berggren, Magnus, Professor, 1968- (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Linköping University, Sweden
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- Svensson, Camilla (author)
- Karolinska Institutet,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Poxson, David, 1979- (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Linköping University, Sweden
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- Simon, Daniel, 1978- (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Linköping University, Sweden
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(creator_code:org_t)
- John Wiley and Sons Inc, 2023
- 2023
- English.
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In: Advanced Healthcare Materials. - : John Wiley and Sons Inc. - 2192-2640 .- 2192-2659. ; 12:24, s. 2300550-
- Related links:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- The organic electronic ion pump (OEIP) is an on-demand electrophoretic drug delivery device, that via electronic to ionic signal conversion enables drug delivery without additional pressure or volume changes. The fundamental component of OEIPs is their polyelectrolyte membranes which are shaped into ionic channels that conduct and deliver ionic drugs, with high spatiotemporal resolution. The patterning of these membranes is essential in OEIP devices and is typically achieved using laborious microprocessing techniques. Here, the development of an inkjet printable formulation of polyelectrolyte is reported, based on a custom anionically functionalized hyperbranched polyglycerol (i-AHPG). This polyelectrolyte ink greatly simplifies the fabrication process and is used in the production of free-standing OEIPs on flexible polyimide (PI) substrates. Both i-AHPG and the OEIP devices are characterized, exhibiting favorable iontronic characteristics of charge selectivity and the ability to transport aromatic compounds. Further, the applicability of these technologies is demonstrated by the transport and delivery of the pharmaceutical compound bupivacaine to dorsal root ganglion cells with high spatial precision and effective nerve blocking, highlighting the applicability of these technologies for biomedical scenarios. © 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
Subject headings
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
Keyword
- bioelectronics
- flexible devices
- inkjet printing
- polyelectrolytes
- polyimide
- Controlled drug delivery
- Fabrication
- Ink jet printing
- Ions
- Polyimides
- Substrates
- Targeted drug delivery
- Bioelectronic
- Bupivacaine
- Flexible device
- Flexible organic electronics
- In-vitro
- Ink-jet printing
- Ion pumps
- Micro-fabrication
- On demands
- Organic electronics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cherian, Dennis, ...
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Roy, Arghyamalya ...
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Bersellini Farin ...
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Abrahamsson, Tob ...
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Arbring Sjöström ...
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Tybrandt, Klas, ...
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Nilsson, David
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Berggren, Magnus ...
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Svensson, Camill ...
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Simon, Daniel, 1 ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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Advanced Healthc ...
- By the university
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RISE
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Karolinska Institutet
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Linköping University