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Nature-Inspired Pep...
Nature-Inspired Peptide Antifouling Biocide : Coating Compatibility, Field Validation, and Environmental Stability
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- Cahill, Patrick (author)
- Cawthron Institute, New Zealand
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- Grant, Thomas (author)
- University of Auckland, New Zealand
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- Rennison, David (author)
- University of Auckland, New Zealand
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- Champeau, Olivier (author)
- Cawthron Institute, New Zealand
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- Boundy, Michael (author)
- Cawthron Institute, New Zealand
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- Passfield, Emillie (author)
- Cawthron Institute, New Zealand
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- Berglin, Mattias (author)
- RISE,Metodik för produktframtagning
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- Brimble, Margaret (author)
- University of Auckland, New Zealand
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- Svenson, Johan (author)
- Cawthron Institute, New Zealand
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(creator_code:org_t)
- American Chemical Society, 2023
- 2023
- English.
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In: ACS Applied Bio Materials. - : American Chemical Society. - 2576-6422. ; 6:6, s. 2415-2425
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- This study reports the development of a class of eco-friendly antifouling biocides based on a cyclic dipeptide scaffold, 2,5-diketopiperazine (2,5-DKP). The lead compound cyclo(N-Bip-l-Arg-N-Bip-l-Arg) (1) was synthesized in gram amounts and used to assess the compatibility with an ablation/hydration coating, efficacy against biofouling, and biodegradation. Leaching of 1 from the coating into seawater was assessed via a rotating drum method, revealing relatively stable and predictable leaching rates under dynamic shear stress conditions (36.1 ± 19.7 to 25.2 ± 9.1 ng-1 cm-2 day-1) but low or no leaching under static conditions. The coatings were further analyzed using time-of-flight secondary ion mass spectrometry (ToF-SIMS), with 1 seen to localize at the surface of the coating in a surfactant-like fashion. When coatings were deployed in the ocean, detectable reductions in biofouling development were measured for up to 11 weeks. After this time, biofouling overwhelmed the performance of the coating, consistent with leaching kinetics. Biodegradation of 1 in seawater was assessed using theoretical oxygen demand and analytical quantification. Masking effects were observed at higher concentrations of 1 due to antimicrobial properties, but half-lives were calculated ranging from 13.4 to 16.2 days. The results can rationally inform future development toward commercial antifouling products.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- 2
- 5-diketopiperazine
- antifouling
- biocide
- eco-friendly
- peptide
- Biofouling
- Disinfectants
- Kinetics
- Peptides
- Biocides
- Biomimetics
- Coatings
- Leaching
- Lead compounds
- Seawater
- Secondary ion mass spectrometry
- Shear stress
- disinfectant agent
- Anti-foulings
- Antifouling biocides
- Cyclic dipeptide
- Diketopiperazines
- Environmental stability
- Field validation
- Rotating drums
- Synthesised
- chemistry
- prevention and control
Publication and Content Type
- ref (subject category)
- art (subject category)
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