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Enzymatic 'stripping' and degradation of PEGylated carbon nanotubes
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- Bhattacharya, Kunal (author)
- Karolinska Institutet
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- Sacchetti, Cristiano (author)
- Sanford Burnham Medical Research Institute, USA
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- El-Sayed, Ramy (author)
- Karolinska Institute, Sweden
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- (creator_code:org_t)
- 2014-10-30
- 2014
- English.
- In: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3364 .- 2040-3372. ; 6:24, s. 14686-14690
- Journal article (peer-reviewed)
Abstract
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- Single-walled carbon nanotubes (SWCNTs) coated or functionalized with PEG chains of different molecular weight were assessed for their propensity to undergo biodegradation under in vitro conditions using recombinant myeloperoxidase (MPO) or ex vivo using freshly isolated primary human neutrophils. Our findings suggest that under natural conditions, a combined process of 'stripping' (i.e., defunctionalization) and biodegradation of PEG-SWCNTs might occur and that PEG-SWCNTs are a promising-and degradable-nanomedicine vector.
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