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Enzymatic 'strippin...
Enzymatic 'stripping' and degradation of PEGylated carbon nanotubes
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- Bhattacharya, Kunal (author)
- Karolinska Institutet
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- Sacchetti, Cristiano (author)
- Sanford Burnham Medical Research Institute, USA
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- El-Sayed, Ramy (author)
- Karolinska Institute, Sweden
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- Fornara, Andrea (author)
- RISE,SP – Sveriges Tekniska Forskningsinstitut
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- Kotchey, Gregg P. (author)
- University of Pittsburgh, USA
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- Gaugler, James A. (author)
- University of Pittsburgh, USA
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- Star, Alexander (author)
- University of Pittsburgh, USA
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- Bottini, Massimo (author)
- Sanford Burnham Medical Research Institute, USA; La Jolla Institute for Allergy and Immunology, USA; University of Rome Tor Vergata, Italy
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- Fadeel, B (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2014-10-30
- 2014
- English.
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In: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3364 .- 2040-3372. ; 6:24, s. 14686-14690
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- Single-walled carbon nanotubes (SWCNTs) coated or functionalized with PEG chains of different molecular weight were assessed for their propensity to undergo biodegradation under in vitro conditions using recombinant myeloperoxidase (MPO) or ex vivo using freshly isolated primary human neutrophils. Our findings suggest that under natural conditions, a combined process of 'stripping' (i.e., defunctionalization) and biodegradation of PEG-SWCNTs might occur and that PEG-SWCNTs are a promising-and degradable-nanomedicine vector.
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- ref (subject category)
- art (subject category)
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