Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents: The HELENA study

Benser, JasminTechnical University of Madrid, Spain; University of Bonn, Germany (author)

Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents : The HELENA study

We examined the association of physical activity (PA), cardiovascular fitness (CVF) and fatness with total homocysteine (tHcy) concentrations in European adolescents. The present study comprised 713 European adolescents aged 14.8±1.2 y (females 55.3%) from the multicenter HELENA cross-sectional study. PA was assessed through accelerometry, CVF by the 20-m shuttle run test, and body fat by skinfold thicknesses with the Slaughter equation. Plasma folate, cobalamin, and tHcy concentrations were measured. To examine the association of tHcy with PA, CVF, and fatness after controlling for a set of confounders including age, maturity, folate, cobalamin, creatinine, smoking, supplement use, and methylenetetrahydrofolate reductase 677 genotype (CC 47%, CT 43%, TT 10%), bivariate correlations followed by multiple regression models were performed. In the bivariate correlation analysis, tHcy concentrations were slightly negatively correlated (p<0.0 5) with CVF in females (measured both by stages: r=-0.118 and by VO 2 max: r=-0.10 2) and positively with body mass index (r=0.10 0). However, daily time spent with moderate and vigorous PA showed a weak positive association with tHcy in females (p<0.0 5). tHcy concentrations showed a tendency to decrease with increasing CVF and increase with increasing BMI in female European adolescents. However, tHcy concentrations were positively associated with moderate and vigorous PA in female European adolescents.

Valtuena, JaraTechnical University of Madrid, Spain (author)
Ruiz, Jonatan R.Karolinska Institutet (author)
Mielgo-Ayuso, JuanTechnical University of Madrid, Spain (author)
Breidenassel, ChristinaTechnical University of Madrid, Spain (author)
Vicente-Rodriguez, GermanUniversity of Zaragoza, Spain (author)
Ferrari, MarikaINRAN Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Italy (author)
Widhalm, KurtPrivate Medical University, Austria (author)
Manios, YannisHarokopio University, Greece (author)
Sjöström, MichaelKarolinska Institutet (author)
Molnar, DenesUniversity of Pécs, Hungary (author)
Gómez-Martínez, SoniaCSIC Spanish National Research Council, Spain (author)
Kafatos, AntonyUniversity of Crete, Greece (author)
Palacios, GonzaloTechnical University of Madrid, Spain; Carlos III Health Institute, Spain (author)
Moreno, Luis A.University of Zaragoza, Spain (author)
Castillo, Manuel J.University of Granada, Spain (author)
Stehle, PeterUniversity of Bonn, Germany (author)
González-Gross, MarcelaTechnical University of Madrid, Spain; University of Bonn, Germany; Carlos III Health Institute, Spain (author)
Hall, GunnarRISE,Flavour (author)
Broberg, AgnetaRISE,Flavour (author)
Åström, AnnikaRISE,Flavour (author)
Technical University of Madrid, Spain; University of Bonn, GermanyTechnical University of Madrid, Spain (creator_code:org_t)

In:Journal of Nutritional Science and Vitaminology: Center for Academic Publications Japan61:1, s. 45-540301-48001881-7742

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