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Identification and ...
Identification and characterization of an anti-pseudomonal dichlorocarbazol derivative displaying anti-biofilm activity
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- Liebens, Veerle R. (author)
- KU Leuven, Belgium
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- Gerits, Evelien (author)
- KU Leuven, Belgium
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- Knapen, Wouter Joris (author)
- KU Leuven, Belgium
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- Swings, Toon (author)
- KU Leuven, Belgium
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- Beullens, Serge (author)
- KU Leuven, Belgium
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- Steenackers, Hans P.L. (author)
- KU Leuven, Belgium
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- Robijns, Stijn Chris Arnold (author)
- KU Leuven, Belgium
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- Lippell, Anna (author)
- University of Leeds, United Kingdom
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- O'Neill, Alex John (author)
- University of Leeds, United Kingdom
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- Veber, Matija (author)
- Educell, Slovenia
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- Fröhlich, Mirjam (author)
- Educell, Slovenia; Jozef Stefan Institute, Slovenia
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- Krona, Annika (author)
- RISE,SIK – Institutet för livsmedel och bioteknik
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- Lövenklev, Maria (author)
- RISE,SIK – Institutet för livsmedel och bioteknik
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- Corbau, Romu (author)
- CISTIM Leuven Vzw, Belgium; Childrens Hospital of Philadelphia, USA
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- Marchand, Arnaud (author)
- CISTIM Leuven Vzw, Belgium
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- Chaltin, Patrick (author)
- CISTIM Leuven Vzw, Belgium; KU Leuven, Belgium
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- de Brucker, Katrijn (author)
- KU Leuven, Belgium
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- Thevissen, Karin (author)
- KU Leuven, Belgium
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- Cammue, Bruno P.A. (author)
- KU Leuven, Belgium; VIB, Belgium
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- Fauvart, Maarten (author)
- KU Leuven, Belgium
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- Verstraeten, Natalie (author)
- KU Leuven, Belgium
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- Michiels, Jan (author)
- KU Leuven, Belgium
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Bioorganic & Medicinal Chemistry Letters. - : Elsevier BV. - 0960-894X .- 1464-3405. ; 24:23, s. 5404-5408
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Pseudomonas aeruginosa strains resistant towards all currently available antibiotics are increasingly encountered, raising the need for new anti-pseudomonal drugs. We therefore conducted a medium-throughput screen of a small-molecule collection resulting in the identification of the N-alkylated 3,6-dihalogenocarbazol 1-(sec-butylamino)-3-(3,6-dichloro-9H-carbazol-9-yl)propan-2-ol (MIC = 18.5 ?g mL-1). This compound, compound 1, is bacteriostatic towards a broad spectrum of Gram-positive and Gram-negative pathogens, including P. aeruginosa. Importantly, 1 also eradicates mature biofilms of P. aeruginosa. 1 displays no cytotoxicity against various human cell types, pointing to its potential for further development as a novel antibacterial drug.
Subject headings
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
Keyword
- Food Engineering
- Livsmedelsteknik
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Liebens, Veerle ...
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Gerits, Evelien
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Knapen, Wouter J ...
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Swings, Toon
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Beullens, Serge
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Steenackers, Han ...
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show more...
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Robijns, Stijn C ...
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Lippell, Anna
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O'Neill, Alex Jo ...
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Veber, Matija
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Fröhlich, Mirjam
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Krona, Annika
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Lövenklev, Maria
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Corbau, Romu
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Marchand, Arnaud
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Chaltin, Patrick
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de Brucker, Katr ...
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Thevissen, Karin
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Cammue, Bruno P. ...
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Fauvart, Maarten
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Verstraeten, Nat ...
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Michiels, Jan
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- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agriculture Fore ...
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and Food Science
- Articles in the publication
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Bioorganic & Med ...
- By the university
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RISE