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Transcriptional act...
Transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish
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- Archer, Amena (author)
- Karolinska Institutet
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- Lauter, Gilbert (author)
- Karolinska Institutet,Södertörns högskola,Institutionen för livsvetenskaper
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- Hauptmann, Giselbert (author)
- Karolinska Institutet,Södertörns högskola,Institutionen för livsvetenskaper
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Mode, Agneta (author)
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Gustafsson, Jan-Ake (author)
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(creator_code:org_t)
- Wiley, 2008
- 2008
- English.
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In: Developmental Dynamics. - : Wiley. - 1058-8388 .- 1097-0177. ; 237:4, s. 1090-1098
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https://doi.org/10.1...
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Abstract
Subject headings
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- Mammalian liver-X-receptors (LXRs) are transcription factors activated by oxysterols. They play an essential role in lipid and glucose metabolism. We have cloned the open reading frame of zebrafish lxr and describe its genomic organization. Zebrafish lxr encodes a 50-kDa protein with high sequence similarity to mammalian LXR alpha. In transfection assays, the encoded protein showed transcriptional activity in response to LXR-ligands. Treatment of adult zebrafish with the synthetic LXR ligand, GW3965, induced expression of genes involved in hepatic cholesterol and lipid pathways. Using qPCR and in situ hybridization, we found ubiquitous expression of lxr mRNA during the first 24 hr of development, followed by more restricted expression, particularly to the liver at 3dpf and the liver and intestine at 4dpf. In adult fish, all examined organs expressed lxr. In addition to a metabolic role of lxr, the temporal expression pattern suggests a developmental role in, e.g., the liver and CNS.
Subject headings
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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