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Functional genomics...
Functional genomics of the cilium, a sensory organelle
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Blacque, O E (author)
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Perens, E A (author)
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Boroevich, K A (author)
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Inglis, P N (author)
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Li, C M (author)
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Warner, A (author)
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Khattra, J (author)
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Holt, R A (author)
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Ou, G S (author)
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Mah, A K (author)
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McKay, S J (author)
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Huang, P (author)
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- Swoboda, Peter (author)
- Karolinska Institutet,Södertörns högskola,Institutionen för livsvetenskaper,Karolinska Institute
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Jones, S J M (author)
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Marra, M A (author)
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Baillie, D L (author)
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Moerman, D G (author)
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Shaham, S (author)
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Leroux, M R (author)
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
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In: Current Biology. - : Elsevier BV. - 0960-9822 .- 1879-0445. ; 15:10, s. 935-941
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Cilia and flagella play important roles in many physiological processes, including cell and fluid movement, sensory perception, and development [1]. The biogenesis and maintenance of cilia depend on intraflagellar transport (IFT), a motility process that operates bidirectionally along the ciliary axoneme [1, 2]. Disruption in IFT and cilia function causes several human disorders, including polycystic kidneys, retinal dystrophy, neurosensory impairment, and Bardet-Bledl syndrome (BBS) [3-5]. To uncover new ciliary components, including IFT proteins, we compared C. elegans ciliated neuronal and nonciliated cells through serial analysis of gene expression (SAGE) and screened for genes potentially regulated by the cillogenic transcription factor, DAF-19 [6]. Using these complementary approaches, we identified numerous candidate ciliary genes and confirmed the ciliated-cell-specific expression of 14 novel genes. One of these, C27H5.7a, encodes a ciliary protein that undergoes IFT. As with other IFT proteins, its ciliary localization and transport is disrupted by mutations in IFT and bbs genes. Furthermore, we demonstrate that the ciliary structural defect of C. elegans dyf-13(mn396) mutants is caused by a mutation in C27H5.7a. Together, our findings help define a ciliary transcriptome and suggest that DYF-13, an evolutionarily conserved protein, is a novel core IFT component required for cilia function.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Blacque, O E
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Perens, E A
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Boroevich, K A
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Inglis, P N
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Li, C M
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Warner, A
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show more...
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Khattra, J
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Holt, R A
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Ou, G S
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Mah, A K
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McKay, S J
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Huang, P
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Swoboda, Peter
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Jones, S J M
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Marra, M A
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Baillie, D L
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Moerman, D G
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Shaham, S
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Leroux, M R
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Current Biology
- By the university
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Södertörn University
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Karolinska Institutet