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Tetrahydroquinoline-Derived Macrocyclic Toolbox : The Discovery of Antiangiogenesis Agents in Zebrafish Assay
- Guduru, Shiva Krishna Reddy (author)
- Chamakuri, Srinivas (author)
-
- Chandrasekar, Gayathri (author)
- Södertörns högskola,Institutionen för naturvetenskap, miljö och teknik
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- Arya, Prabhat (author)
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- (creator_code:org_t)
- 2013-05-30
- 2013
- English.
- In: ACS Medicinal Chemistry Letters. - : American Chemical Society (ACS). - 1948-5875. ; 4:7, s. 666-670
- Journal article (peer-reviewed)
Abstract
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- A novel approach to incorporate the macrocyclic rings onto the privileged substructure, i.e. tetrahydroquinoline scaffold, is developed. The presence of an amino acid-derived moiety in the macrocyclic skeleton provides an opportunity to modulate the nature of the chiral side chain. Further, evaluation in a zebrafish screen identified three active small molecules (2.5b, 3.2d, and 4.2) as antiangiogenesis agents at 2.5 mu M.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
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