onr:"swepub:oai:DiVA.org:sh-29021"
Search: onr:"swepub:oai:DiVA.org:sh-29021" > A proteinaceous gen...
- 1 of 1
- Previous record
- Next record
- To hitlist
A proteinaceous gene regulatory thermometer in Salmonella
- Hurme, R (author)
-
- Berndt, Kurt D (author)
- Karolinska Institutet
- Normark, S J (author)
- show more...
- show less...
- (creator_code:org_t)
- 1997
- 1997
- English.
- In: Cell. - 0092-8674 .- 1097-4172. ; 90:1, s. 55-64
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Novel utilization of the coiled-coil motif is presented that enables TlpA, an autoregulatory repressor protein in Salmonella, to sense temperature shifts directly and thereby to modulate the extent of transcription repression. Salmonella cells shifted to higher temperatures, such as those encountered at host entry, showed derepressed tlpA activity. tlpA::lacZ fusions indicated that the promoter itself is insensitive to thermal shifts and that transcription control was exerted by the autorepressor TlpA only. In vitro studies with highly purified TlpA showed concentration and temperature dependence for both fully folded conformation and function, indicating that the thermosensing in TlpA is based on monomer-to-coiled-coil equilibrium.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- DNA-binding
- environmental-regulation
- escherichia-coli
- heat-shock
- helical coiled-coils
- pathogenic bacteria
- shigella-flexneri
- shock transcription factor-1
- smooth-muscle tropomyosin
- temperature regulation
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Hurme, R
- Berndt, Kurt D
- Normark, S J
- Rhen, M
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Biochemistry and ...
- Articles in the publication
- Cell
- By the university
- Södertörn University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
