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Psychological burde...
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Shor-Posner, G.Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States
(author)
Psychological burden in the era of Haart : Impact of selenium therapy
- Article/chapterEnglish2003
Publisher, publication year, extent ...
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Sage Publications,2003
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Numbers
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LIBRIS-ID:oai:DiVA.org:sh-45214
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https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-45214URI
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https://doi.org/10.2190/PFFD-D920-V041-N5KDDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-27956URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Objective: To determine the impact of nutritional (selenium) chemoprevention on levels of psychological burden (anxiety, depression, and mood state) in HIV/AIDS. Method: A randomized, double-blind, placebo-controlled selenium therapy (200 mug/day) trial was conducted in HIV+ drug users from 1998-2000. Psychosocial measures (STAI-State and Trait anxiety, BDI-depression, and POMS- mood state), clinical status (CD4 cell count, viral load), and plasma selenium levels were determined at baseline and compared with measurements obtained at the 12-month evaluation in 63 participants (32 men, 31 women). Results: The majority of the study participants reported elevated levels of both State (68%) and Trait (70%) anxiety. Approximately 25% reported overall mood distress (POMS > 60) and moderate depression (BDI > 20). Psychological burden was not influenced by current drug use, antiretroviral treatment, or viral load. At the 12-month evaluation, participants who received selenium reported increased vigor (p = 0.004) and had less anxiety (State, p = 0.05 and Trait, p = 0.02), compared to the placebo-treated individuals. No apparent selenium-related affect on depression or distress was observed. The risk for state anxiety was almost four times higher, and nearly nine times greater for trait anxiety in the placebo-treated group, controlling for antiretroviral therapy, CD4 cell decline (> 50 cells) and years of education. Conclusions: Selenium therapy may be a beneficial treatment to decrease anxiety in HIV+ drug users who exhibit a high prevalence of psychological burden.
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Lecusay, Robert,1974-Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States(Swepub:hj)lecrob
(author)
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Miguez, M. J.Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States
(author)
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Moreno-Black, G.Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States
(author)
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Zhang, G. Y.Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States
(author)
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Rodriguez, N.Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States
(author)
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Burbano, X.Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States
(author)
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Baum, M.Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States
(author)
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Wilkie, F.Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States
(author)
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Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States
(creator_code:org_t)
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In:International Journal of Psychiatry in Medicine: Sage Publications33:1, s. 55-690091-21741541-3527
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Shor-Posner, G.
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Lecusay, Robert, ...
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Miguez, M. J.
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Moreno-Black, G.
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Zhang, G. Y.
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Rodriguez, N.
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Burbano, X.
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Baum, M.
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Wilkie, F.
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and Psychiatry
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Södertörn University
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Jönköping University