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- Vanpouille, Christophe (author)
The progestin medroxyprogesterone acetate affects HIV-1 production in human lymphoid tissue explants in a dose-dependent and glucocorticoid-like fashion
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-11-18
- MDPI AG,2021
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:shh-4270
- https://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-4270URI
- https://doi.org/10.3390/v13112303DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:148317819URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- The association between the use of the injectable contraceptive depot medroxyprogesterone acetate and HIV-1 susceptibility has been addressed mainly in respect to the changes occurring in the female genital mucosa and blood. However, one of the main sites of HIV-1 pathogenesis is lymphoid organs. To investigate the immunoregulatory effect of medroxyprogesterone acetate (MPA) at this site, human tonsillar tissue explants were infected ex vivo with either a CCR5 (BaL) or CXCR4 (LAI) HIV-1 variant and the release of p24gag and cytokines was measured in culture supernatant. The response to MPA was compared with that elicited by treatment with progesterone (P4) and dexamethasone (DEX), which selectively binds the glucocorticoid receptor, in donor-matched explant cultures. MPA treatment reduced the replication of both tested HIV-1 strains as well as the production of the mediators of inflammation IL-1β, IL-17A and CCL5, but not CCL20, in a similar way to DEX, whereas P4 had no effect on HIV-1 replication. The magnitude of both MPA and DEX-mediated responses was proportional to the length of exposure and/or administered dose. Blockage of the progesterone and glucocorticoid receptors with mifepristone abolished all observed changes in HIV-1 and cytokine production, and was associated with increased IL-22 levels in HIV-infected explants. Our data indicate that elevated doses of MPA may affect the immune responses in lymphoid tissue in a glucocorticoid-like fashion with an immediate impact on local HIV-1 replication.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
- DMPA
- HIV-1
- Cytokines
- Glucocorticoids
- Hormonal contraception
- Lymphoid tissue
- Progesterone
- Sex hormones
- Tissue explants
- Tonsils
Added entries (persons, corporate bodies, meetings, titles ...)
- Günaydın, Gökçe (author)
- Jangard, MattiasSophiahemmet Högskola(Swepub:shh)mattiasja (author)
- Clerici, Mario (author)
- Margolis, Leonid (author)
- Broliden, KristinaKarolinska Institutet (author)
- Introini, AndreaKarolinska Institutet (author)
- Karolinska InstitutetSophiahemmet Högskola (creator_code:org_t)
Related titles
- In:Viruses: MDPI AG13:111999-4915
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