Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3

AuthorCount:4;
Bombesin receptor subtype-3 (BRS-3) regulates energy homeostasis, with Brs3 knockout (Brs3(-/y)) mice being hypometabolic, hypothermic, and hyperphagic and developing obesity. We now report that the reduced body temperature is more readily detected if body temperature is analyzed as a function of physical activity level and light/dark phase. Physical activity level correlated best with body temperature 4 min later. The Brs3(-/y) metabolic phenotype is not due to intrinsically impaired brown adipose tissue function or in the communication of sympathetic signals from the brain to brown adipose tissue, since Brs3(-/y) mice have intact thermogenic responses to stress, acute cold exposure, and beta 3-adrenergic activation, and Brs3(-/y) mice prefer a cooler environment. Treatment with the BRS-3 agonist MK-5046 increased brown adipose tissue temperature and body temperature in wild-type but not Brs3(-/y) mice. Intrahypothalamic infusion of MK5046 increased body temperature. These data indicate that the BRS-3 regulation of body temperature is via a central mechanism, upstream of sympathetic efferents. The reduced body temperature in Brs3(-/y) mice is due to altered regulation of energy homeostasis affecting higher center regulation of body temperature, rather than an intrinsic defect in brown adipose tissue.

Abreu-Vieira, GustavoStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)gdeab (author)
Xiao, Cuiying (author)
Reitman, Marc L. (author)
Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut (creator_code:org_t)

In:American Journal of Physiology. Endocrinology and Metabolism: American Physiological Society306:6, s. E681-E6870193-18491522-1555

By the author/editor: Lateef, Dalya M.; Abreu-Vieira, Gu ...; Xiao, Cuiying; Reitman, Marc L.

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