Accurate macromolecular structures using minimal measurements from X-ray free-electron lasers

AuthorCount:41;
X-ray free-electron laser (XFEL) sources enable the use of crystallography to solve three-dimensional macromolecular structures under native conditions and without radiation damage. Results to date, however, have been limited by the challenge of deriving accurate Bragg intensities from a heterogeneous population of microcrystals, while at the same time modeling the X-ray spectrum and detector geometry. Here we present a computational approach designed to extract meaningful high-resolution signals from fewer diffraction measurements.

Echols, Nathaniel (author)
Tran, Rosalie (author)
Kern, Jan (author)
Gildea, Richard J. (author)
Brewster, Aaron S. (author)
Alonso-Mori, Roberto (author)
Gloeckner, Carina (author)
Hellmich, Julia (author)
Laksmono, Hartawan (author)
Sierra, Raymond G. (author)
Lassalle-Kaiser, Benedikt (author)
Lampe, Alyssa (author)
Han, Guangye (author)
Gul, Sheraz (author)
DiFiore, Doerte (author)
Milathianaki, Despina (author)
Fry, Alan R. (author)
Miahnahri, Alan (author)
White, William E. (author)
Schafer, Donald W. (author)
Seibert, M. Marvin (author)
Koglin, Jason E. (author)
Sokaras, Dimosthenis (author)
Weng, Tsu-Chien (author)
Sellberg, JonasStockholms universitet,Fysikum,SLAC National Accelerator Laboratory, USA(Swepub:su)jose4950 (author)
Latimers, Matthew J. (author)
Glatzel, Pieter (author)
Zwart, Petrus H. (author)
Grosse-Kunstleve, Ralf W. (author)
Bogan, Michael J. (author)
Messerschmidt, Marc (author)
Williams, Garth J. (author)
Boutet, Sebastien (author)
Messinger, JohannesUmeå universitet,Kemiska institutionen(Swepub:umu)jome0007 (author)
Zouni, Athina (author)
Yano, Junko (author)
Bergmann, Uwe (author)
Yachandra, Vittal K. (author)
Adams, Paul D. (author)
Sauter, Nicholas K. (author)
Stockholms universitetFysikum (creator_code:org_t)

By the author/editor: Hattne, Johan; Echols, Nathanie ...; Tran, Rosalie; Kern, Jan; Gildea, Richard ...; Brewster, Aaron ...; show more...; Alonso-Mori, Rob ...; Gloeckner, Carin ...; Hellmich, Julia; Laksmono, Hartaw ...; Sierra, Raymond ...; Lassalle-Kaiser, ...; Lampe, Alyssa; Han, Guangye; Gul, Sheraz; DiFiore, Doerte; Milathianaki, De ...; Fry, Alan R.; Miahnahri, Alan; White, William E ...; Schafer, Donald ...; Seibert, M. Marv ...; Koglin, Jason E.; Sokaras, Dimosth ...; Weng, Tsu-Chien; Sellberg, Jonas; Latimers, Matthe ...; Glatzel, Pieter; Zwart, Petrus H.; Grosse-Kunstleve ...; Bogan, Michael J ...; Messerschmidt, M ...; Williams, Garth ...; Boutet, Sebastie ...; Messinger, Johan ...; Zouni, Athina; Yano, Junko; Bergmann, Uwe; Yachandra, Vitta ...; Adams, Paul D.; Sauter, Nicholas ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Physical Science ...; and Atom and Molecul ...

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