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Do cardiovascular r...
Do cardiovascular risk factors explain the link between white matter hyperintensities and brain volumes in old age? : A population-based study
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- Wang, R. (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet (KI) − Stockholm University, Stockholm, Sweden
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- Fratiglioni, L. (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet (KI) − Stockholm University, Stockholm, Sweden and Stockholm Gerontology Research Center, Stockholm, Sweden
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- Laveskog, A. (author)
- Karolinska Institutet
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- Kalpouzos, G. (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet (KI) − Stockholm University, Stockholm, Sweden
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- Ehrenkrona, C. -H (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet (KI) − Stockholm University, Stockholm, Sweden
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- Zhang, Y. (author)
- Umeå universitet,Diagnostisk radiologi
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- Bronge, L. (author)
- Karolinska Institutet
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- Wahlund, L. -O (author)
- Karolinska Institutet
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- Bäckman, L. (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet (KI) − Stockholm University, Stockholm, Sweden and Stockholm Gerontology Research Center, Stockholm, Sweden
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- Qiu, C. (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet (KI) − Stockholm University, Stockholm, Sweden
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(creator_code:org_t)
- 2013-12-07
- 2014
- English.
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In: European Journal of Neurology. - : Wiley. - 1351-5101 .- 1468-1331. ; 21:8, s. 1076-1082
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background and purpose: White matter hyperintensities (WMHs) and brain atrophy frequently coexist in older people. However, it is unclear whether the association between these two brain lesions is dependent on the aging process, a vascular mechanism or genetic susceptibility. It was therefore investigated whether the association between load of WMHs and brain atrophy measures is related to age, vascular risk factors (VRFs) or the APOE-epsilon 4 allele. Methods: This population-based study included 492 participants (age >= 60 years, 59.6% women) free of dementia and stroke. Data on demographics, VRFs and APOE genotypes were collected through interviews, clinical examination and laboratory tests. WMHs on magnetic resonance images were assessed using manual visual rating and automatic volumetric segmentation. Hippocampal and ventricular volumes were manually delineated, whereas total gray matter (GM) volume was measured by automatic segmentation. Data were analyzed with multivariate linear regression models. Results: More global WMHs, assessed using either a visual rating scale or a volumetric approach, were significantly associated with lower GM volume and higher ventricular volume; the associations remained significant after adjusting for age, VRFs and the APOE-epsilon 4 allele. In contrast, the association between global WMHs and hippocampal volume was no longer significant after adjusting for age, whereas adjustment for VRFs and APOE-epsilon 4 had no influential effect. Conclusion: The association of global WMHs with lower GM volume and higher ventricular volume is independent of age, VRFs and APOE-epsilon 4 allele, suggesting that the process of cerebral microvascular disease and neurodegeneration are associated independently of the normal aging process, vascular mechanisms or genetic susceptibility.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- aging
- APOE genotype
- brain volume
- hippocampal volume
- population-based study
- vascular risk factors
- white matter hyperintensities
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Wang, R.
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Fratiglioni, L.
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Laveskog, A.
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Kalpouzos, G.
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Ehrenkrona, C. - ...
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Zhang, Y.
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show more...
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Bronge, L.
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Wahlund, L. -O
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Bäckman, L.
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Qiu, C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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European Journal ...
- By the university
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Stockholm University
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Umeå University
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Karolinska Institutet