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Dopamine release in...
Dopamine release in nucleus accumbens during rewarded task switching measured by [C-11]raclopride
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- Jonasson, Lars S. (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Centrum för befolkningsstudier (CBS)
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- Axelsson, Jan (author)
- Umeå universitet,Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Riklund, Katrine (author)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Braver, Todd S. (author)
- Department of Psychology,Washington University, St Louis, MO 63130, USA
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- Ögren, Mattias (author)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Bäckman, Lars (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center, Karolinska Institute, SE-113 30 Stockholm, Sweden
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- Nyberg, Lars (author)
- Umeå universitet,Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: NeuroImage. - : Elsevier BV. - 1053-8119 .- 1095-9572. ; 99, s. 357-364
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Abstract
Subject headings
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- Reward and motivation have positive influences on cognitive-control processes in numerous settings. Models of reward implicate corticostriatal loops and the dopamine (DA) system, with special emphasis on D-2 receptors in nucleus accumbens (NAcc). In this study, 11 right-handed males (35-40 years) were scanned with positron emission tomography (PET) in a single [C-11]raclopride dynamic scan during rewarded and non-rewarded task switching. Rewarded task switching (relative to baseline task switching) decreased [11C]raclopride binding in NAcc. Decreasing NAcc [C-11]raclopride binding was strongly associated with task reaction time measures that reflect individual differences in effort and control strategies. Voxelwise analyses additionally revealed reward-related DA release in anterodorsal caudate, a region previously associated with task-switching. These PET findings provide evidence for striatal DA release during motivated cognitive control, and further suggest that NAcc DA release predicts the task reaction time benefits of reward incentives.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Reward
- Dopamine
- PET
- Nucleus accumbens
- Working memory
- Motivation
Publication and Content Type
- ref (subject category)
- art (subject category)
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