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Large pore mesoporo...
Large pore mesoporous silica induced weight loss in obese mice
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Kupferschmidt, Natalia (author)
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- Csikasz, Robert I. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Ballell, Lluis (author)
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- Bengtsson, Tore (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Garcia-Bennett, Alfonso E. (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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(creator_code:org_t)
- 2014
- 2014
- English.
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In: Nanomedicine. - 1743-5889 .- 1748-6963. ; 9:9, s. 1353-1362
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Background: There is a need for medical treatments to curb the rising rate of obesity. Weight reduction is correlated with a decrease in associated risk factors and cholesterol levels in humans. Amorphous silica particles have been found to exert a hypocholesterolemic effect in humans, making them popular dietary additives. Aim: To investigate the effect of mesoporous silica, which possess sharp pore size distributions, on: weight loss, cholesterol, triglycerides and glucose blood levels in obese mice. Materials & methods: Mesoporous silicas with differing pore size were mixed in the high-fat diet of obese mice. Results: Animals receiving large pore mesoporous silica with a high-fat diet show a significant reduction in body weight and fat composition, with no observable negative effects. Conclusion: Pore size is an important parameter for reduction of body weight and body fat composition by mesoporous silica, demonstrating promising signs for the treatment of obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- body fat
- body weight
- cholesterol
- high-fat diet
- mesoporous silica
- obesity
Publication and Content Type
- ref (subject category)
- art (subject category)
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