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Are air pollution a...
Are air pollution and traffic noise independently associated with atherosclerosis : the Heinz Nixdorf Recall Study
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2013-11-04
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Oxford University Press (OUP),2014
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:su-111149
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-111149URI
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https://doi.org/10.1093/eurheartj/eht426DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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AIMS: Living close to high traffic has been linked to subclinical atherosclerosis, however it is not clear, whether fine particulate matter (PM) air pollution or noise, two important traffic-related exposures, are responsible for the association. We investigate the independent associations of long-term exposure to fine PM and road traffic noise with thoracic aortic calcification (TAC), a reliable measure of subclinical atherosclerosis.METHODS AND RESULTS: We used baseline data (2000-2003) from the German Heinz Nixdorf Recall Study, a population-based cohort of 4814 randomly selected participants. We assessed residential long-term exposure to PM with a chemistry transport model, and to road traffic noise using façade levels from noise models as weighted 24 h mean noise (Lden) and night-time noise (Lnight). Thoracic aortic calcification was quantified from non-contrast enhanced electron beam computed tomography. We used multiple linear regression to estimate associations of environmental exposures with ln(TAC+1), adjusting for each other, individual, and neighbourhood characteristics. In 4238 participants (mean age 60 years, 49.9% male), PM2.5 (aerodynamic diameter ≤2.5 µm) and Lnight are both associated with an increasing TAC-burden of 18.1% (95% CI: 6.6; 30.9%) per 2.4 µg/m(3) PM2.5 and 3.9% (95% CI 0.0; 8.0%) per 5dB(A) Lnight, respectively, in the full model and after mutual adjustment. We did not observe effect measure modification of the PM2.5 association by Lnight or vice versa.CONCLUSION: Long-term exposure to fine PM and night-time traffic noise are both independently associated with subclinical atherosclerosis and may both contribute to the association of traffic proximity with atherosclerosis.
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Hennig, Frauke
(author)
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Moebus, Susanne
(author)
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Möhlenkamp, Stefan
(author)
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Dragano, Nico
(author)
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Jakobs, Hermann
(author)
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Memmesheimer, Michael
(author)
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Erbel, Raimund
(author)
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Jöckel, Karl-Heinz
(author)
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Hoffmann, Barbara
(author)
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Roggenbuck, U
(author)
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Slomiany, U.
(author)
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Beck, E. M.
(author)
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Offner, A.
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Münkel, S.
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Schrader, S.
(author)
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Peter, R.
(author)
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Hirche, H.
(author)
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Meinertz, T.
(author)
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Bode, C.
(author)
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Defeyter, P. J.
(author)
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Güntert, B.
(author)
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Halli, T.
(author)
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Gutzwiller, F.
(author)
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Heinen, H.
(author)
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Hess, O.
(author)
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Klein, B.
(author)
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Löwel, H.
(author)
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Reiser, M.
(author)
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Schmidt, G.
(author)
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Schwaiger, M.
(author)
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Steinmüller, C.
(author)
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Theorell, TöresStockholms universitet,Stressforskningsinstitutet(Swepub:su)ttheo
(author)
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Willich, S. N.
(author)
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Stockholms universitetStressforskningsinstitutet
(creator_code:org_t)
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In:European Heart Journal: Oxford University Press (OUP)35:13, s. 853-600195-668X1522-9645
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- By the author/editor
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Kälsch, Hagen
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Hennig, Frauke
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Moebus, Susanne
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Möhlenkamp, Stef ...
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Dragano, Nico
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Jakobs, Hermann
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Memmesheimer, Mi ...
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Erbel, Raimund
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Jöckel, Karl-Hei ...
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Hoffmann, Barbar ...
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Roggenbuck, U
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Slomiany, U.
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Beck, E. M.
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Offner, A.
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Münkel, S.
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Schrader, S.
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Peter, R.
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Hirche, H.
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Meinertz, T.
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Bode, C.
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Defeyter, P. J.
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Güntert, B.
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Halli, T.
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Gutzwiller, F.
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Heinen, H.
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Hess, O.
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Klein, B.
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Löwel, H.
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Reiser, M.
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Schmidt, G.
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Schwaiger, M.
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Steinmüller, C.
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Theorell, Töres
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Willich, S. N.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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European Heart J ...
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Stockholm University