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GABAergic Terminals...
GABAergic Terminals Are a Source of Galanin to Modulate Cholinergic Neuron Development in the Neonatal Forebrain
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- Keimpema, Erik (author)
- Karolinska Institutet
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Zheng, Kang (author)
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- Barde, Swapnali Shantaram (author)
- Karolinska Institutet
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Berghuis, Paul (author)
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Dobszay, Marton B. (author)
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- Schnell, Robert (author)
- Karolinska Institutet
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- Mulder, Jan (author)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Karolinska Institute, Sweden
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Luiten, Paul G. M. (author)
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Xu, Zhiqing David (author)
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- Runesson, Johan (author)
- Stockholms universitet,Institutionen för neurokemi
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- Langel, Ülo (author)
- Stockholms universitet,Institutionen för neurokemi
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Lu, Bai (author)
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- Hokfelt, Tomas (author)
- Karolinska Institutet
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- Harkany, Tibor (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2013-07-29
- 2014
- English.
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In: Cerebral Cortex. - : Oxford University Press (OUP). - 1047-3211 .- 1460-2199. ; 24:12, s. 3277-3288
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The distribution and (patho-) physiological role of neuropeptides in the adult and aging brain have been extensively studied. Galanin is an inhibitory neuropeptide that can coexist with.-aminobutyric acid (GABA) in the adult forebrain. However, galanin's expression sites, mode of signaling, impact on neuronal morphology, and colocalization with amino acid neurotransmitters during brain development are less well understood. Here, we show that galaninergic innervation of cholinergic projection neurons, which preferentially express galanin receptor 2 (GalR2) in the neonatal mouse basal forebrain, develops by birth. Nerve growth factor (NGF), known to modulate cholinergic morphogenesis, increases GalR2 expression. GalR2 antagonism (M871) in neonates reduces the in vivo expression and axonal targeting of the vesicular acetylcholine transporter (VAChT), indispensable for cholinergic neurotransmission. During cholinergic neuritogenesis in vitro, GalR2 can recruit Rho-family GTPases to induce the extension of a VAChT-containing primary neurite, the prospective axon. In doing so, GalR2 signaling dose-dependently modulates directional filopodial growth and antagonizes NGF-induced growth cone differentiation. Galanin accumulates in GABA-containing nerve terminals in the neonatal basal forebrain, suggesting its contribution to activity-driven cholinergic development during the perinatal period. Overall, our data define the cellular specificity and molecular complexity of galanin action in the developing basal forebrain.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- axon
- basal forebrain
- galanin receptor 2
- neurotrophin
- projection
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Keimpema, Erik
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Zheng, Kang
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Barde, Swapnali ...
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Berghuis, Paul
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Dobszay, Marton ...
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Schnell, Robert
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show more...
-
Mulder, Jan
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Luiten, Paul G. ...
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Xu, Zhiqing Davi ...
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Runesson, Johan
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Langel, Ülo
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Lu, Bai
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Hokfelt, Tomas
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Harkany, Tibor
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Cerebral Cortex
- By the university
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Stockholm University
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Royal Institute of Technology
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Karolinska Institutet