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Is Fc gamma recepto...
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Cherif, Mariama K.
(author)
Is Fc gamma receptor IIA (Fc gamma RIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso?
- Article/chapterEnglish2015
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Elsevier BV,2015
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LIBRIS-ID:oai:DiVA.org:su-115280
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-115280URI
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https://doi.org/10.1016/j.actatropica.2014.09.019DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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AuthorCount:12;
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In the present study, the influences of Fc gamma RIIA polymorphism on susceptibility to malaria and antibody responses to Plasmodium falciparum antigens were analyzed in children. We recruited 96 healthy children between 3 and 10 years at the beginning of the high transmission season and we followed up for 5 months through the high transmission season to assess the parasitological, immunological and genetic endpoints in relation to clinical malaria status. There was a similar distribution of homozygous and heterozygous individuals carrying the Fc gamma RIIA-131R/R and Fc gamma RIIA-131R/H allele, whereas the number of Fc gamma RIIA-131H/H homozygous individuals was lower. P. falciparum infection frequency was not associated with the Fc gamma RIIa-131R/H polymorphism. Only IgG antibody responses to GLURP R0 showed a significant association between antibody levels and Fc gamma RIIA polymorphism (p = 0.02). IgG levels to MSP2a were significantly higher in children who did not experience any clinical malaria episode compared to those who experienced at least one malaria episode (p = 0.019). Cytophilic and non-cytophylic IgG subclass levels were higher in children without malaria than those who experienced at least one malaria episode. This difference was statistically significant for IgG1 to MSP3 (p = 0.003) and to MSP2a (p = 0.006); IgG3 to MSP2a (p = 0.007) and to GLURP R0 (p = 0.044); IgG2 to MSP2b (p = 0.007) and IgG4 to MSP3 (p = 0.051) and to MSP2a (p = 0.049). In this study, homozygous carriers of the Fc gamma RIIA-131R/R allele had higher malaria-specific antibody levels compare to the heterozygous carriers Fc gamma RIIA-131R/H alleles and to homozygous carriers of Fc gamma RIIA-131H/H alleles. The pre-existing antibodies responses were related to a reduced subsequent risk of clinical malaria.
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Sanou, Guillaume S.
(author)
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Bougouma, Edith C.
(author)
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Diarra, Amidou
(author)
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Ouedraogo, Alphonse
(author)
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Dolo, Amagana
(author)
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Troye-Blomberg, MaritaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)marita
(author)
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Cavanagh, David R.
(author)
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Theisen, Michael
(author)
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Modiano, David
(author)
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Sirima, Sodiomon B.
(author)
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Nebie, Issa
(author)
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Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut
(creator_code:org_t)
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In:Acta Tropica: Elsevier BV142, s. 41-460001-706X1873-6254
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Diarra, Amidou
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Ouedraogo, Alpho ...
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Dolo, Amagana
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Troye-Blomberg, ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Acta Tropica
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Stockholm University