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Genetic contributio...
Genetic contributions to variation in general cognitive function : a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
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Davies, G. (author)
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Armstrong, N. (author)
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Bis, J. C. (author)
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show more...
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Bressler, J. (author)
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Chouraki, V. (author)
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Giddaluru, S. (author)
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Hofer, E. (author)
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Ibrahim-Verbaas, C. A. (author)
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Kirin, M. (author)
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Lahti, J. (author)
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van der Lee, S. J. (author)
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Le Hellard, S. (author)
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Liu, T. (author)
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Marioni, R. E. (author)
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Oldmeadow, C. (author)
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Postmus, I. (author)
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Smith, A. V. (author)
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Smith, J. A. (author)
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Thalamuthu, A. (author)
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Thomson, R. (author)
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Vitart, V. (author)
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Wang, J. (author)
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Yu, L. (author)
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Zgaga, L. (author)
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Zhao, W. (author)
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Boxall, R. (author)
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Harris, S. E. (author)
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Hill, W. D. (author)
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Liewald, D. C. (author)
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Luciano, M. (author)
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Adams, H. (author)
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Ames, D. (author)
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Amin, N. (author)
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Amouyel, P. (author)
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Assareh, A. A. (author)
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Au, R. (author)
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Becker, J. T. (author)
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Beiser, A. (author)
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Berr, C. (author)
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Bertram, L. (author)
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Boerwinkle, E. (author)
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Buckley, B. M. (author)
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Campbell, H. (author)
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Corley, J. (author)
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De Jager, P. L. (author)
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Dufouil, C. (author)
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Eriksson, J. G. (author)
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Espeseth, T. (author)
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Faul, J. D. (author)
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Ford, I. (author)
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Gottesman, R. F. (author)
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Griswold, M. E. (author)
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Gudnason, V. (author)
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Harris, T. B. (author)
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Heiss, G. (author)
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Hofman, A. (author)
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Holliday, E. G. (author)
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Huffman, J. (author)
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Kardia, S. L. R. (author)
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Kochan, N. (author)
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Knopman, D. S. (author)
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Kwok, J. B. (author)
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Lambert, J-C (author)
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Lee, T. (author)
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Li, G. (author)
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Li, S-C (author)
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Loitfelder, M. (author)
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Lopez, O. L. (author)
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Lundervold, A. J. (author)
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- Lundquist, Anders (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)
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Mather, K. A. (author)
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Mirza, S. S. (author)
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- Nyberg, Lars (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI)
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Oostra, B. A. (author)
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Palotie, A. (author)
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- Papenberg, Goran (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Max Planck Institute for Human Development, Germany
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Pattie, A. (author)
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Petrovic, K. (author)
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Polasek, O. (author)
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Psaty, B. M. (author)
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Redmond, P. (author)
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Reppermund, S. (author)
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Rotter, J. I. (author)
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Schmidt, H. (author)
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Schuur, M. (author)
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Schofield, P. W. (author)
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Scott, R. J. (author)
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Steen, V. M. (author)
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Stott, D. J. (author)
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Van Swieten, J. C. (author)
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Taylor, K. D. (author)
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Trollor, J. (author)
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Trompet, S. (author)
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Uitterlinden, A. G. (author)
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Weinstein, G. (author)
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Widen, E. (author)
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Windham, B. G. (author)
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Jukema, J. W. (author)
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Wright, A. F. (author)
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Wright, M. J. (author)
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Yang, Q. (author)
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Amieva, H. (author)
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Attia, J. R. (author)
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Bennett, D. A. (author)
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Brodaty, H. (author)
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de Craen, A. J. M. (author)
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Hayward, C. (author)
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Ikram, M. A. (author)
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Lindenberger, U. (author)
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- Nilsson, Lars-Göran (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),ARC, Karolinska Institutet, Stockholm
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Porteous, D. J. (author)
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Raikkonen, K. (author)
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Reinvang, I. (author)
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Rudan, I. (author)
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Sachdev, P. S. (author)
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Schmidt, R. (author)
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Schofield, P. R. (author)
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Srikanth, V. (author)
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Starr, J. M. (author)
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Turner, S. T. (author)
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Weir, D. R. (author)
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Wilson, J. F. (author)
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Van Duijn, C. (author)
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Launer, L. (author)
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Fitzpatrick, A. L. (author)
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Seshadri, S. (author)
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Jr, T. H. Mosley (author)
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Deary, I. J. (author)
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(creator_code:org_t)
- 2015-02-03
- 2015
- English.
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In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 20:2, s. 183-192
- Related links:
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https://doi.org/10.1...
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https://www.nature.c...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health-and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N = 53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P = 3.93 x 10(-9), MIR2113; rs17522122, P = 2.55 x 10(-8), AKAP6; rs10119, P = 5.67 x 10(-9), APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P = 1x10(-6)). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N = 6617) and the Health and Retirement Study (N = 5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e. = 5%) and 28% (s.e. = 7%), respectively. Using polygenic prediction analysis, similar to 1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N = 5487; P = 1.5 x 10(-17)). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Davies, G.
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Armstrong, N.
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Bis, J. C.
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Bressler, J.
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Chouraki, V.
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Giddaluru, S.
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show more...
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Hofer, E.
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Ibrahim-Verbaas, ...
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Kirin, M.
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Lahti, J.
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van der Lee, S. ...
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Le Hellard, S.
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Liu, T.
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Marioni, R. E.
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Oldmeadow, C.
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Postmus, I.
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Smith, A. V.
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Smith, J. A.
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Thalamuthu, A.
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Thomson, R.
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Vitart, V.
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Wang, J.
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Yu, L.
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Zgaga, L.
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Zhao, W.
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Boxall, R.
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Harris, S. E.
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Hill, W. D.
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Liewald, D. C.
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Luciano, M.
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Adams, H.
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Ames, D.
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Amin, N.
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Amouyel, P.
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Assareh, A. A.
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Au, R.
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Becker, J. T.
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Beiser, A.
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Berr, C.
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Bertram, L.
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Boerwinkle, E.
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Buckley, B. M.
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Campbell, H.
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Corley, J.
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De Jager, P. L.
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Dufouil, C.
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Eriksson, J. G.
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Espeseth, T.
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Faul, J. D.
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Ford, I.
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Gottesman, R. F.
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Griswold, M. E.
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Gudnason, V.
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Harris, T. B.
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Heiss, G.
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Hofman, A.
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Holliday, E. G.
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Huffman, J.
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Kardia, S. L. R.
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Kochan, N.
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Knopman, D. S.
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Kwok, J. B.
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Lambert, J-C
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Lee, T.
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Li, G.
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Li, S-C
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Loitfelder, M.
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Lopez, O. L.
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Lundervold, A. J ...
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Lundquist, Ander ...
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Mather, K. A.
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Mirza, S. S.
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Nyberg, Lars
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Oostra, B. A.
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Palotie, A.
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Papenberg, Goran
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Pattie, A.
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Petrovic, K.
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Polasek, O.
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Psaty, B. M.
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Redmond, P.
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Reppermund, S.
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Rotter, J. I.
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Schmidt, H.
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Schuur, M.
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Schofield, P. W.
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Scott, R. J.
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Steen, V. M.
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Stott, D. J.
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Van Swieten, J. ...
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Taylor, K. D.
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Trollor, J.
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Trompet, S.
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Uitterlinden, A. ...
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Weinstein, G.
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Widen, E.
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Windham, B. G.
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Jukema, J. W.
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Wright, A. F.
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Wright, M. J.
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Yang, Q.
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Amieva, H.
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Attia, J. R.
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Bennett, D. A.
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Brodaty, H.
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de Craen, A. J. ...
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Hayward, C.
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Ikram, M. A.
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Lindenberger, U.
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Nilsson, Lars-Gö ...
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Porteous, D. J.
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Raikkonen, K.
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Reinvang, I.
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Rudan, I.
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Sachdev, P. S.
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Schmidt, R.
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Schofield, P. R.
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Srikanth, V.
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Starr, J. M.
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Turner, S. T.
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Weir, D. R.
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Wilson, J. F.
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Van Duijn, C.
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Launer, L.
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Fitzpatrick, A. ...
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Seshadri, S.
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Jr, T. H. Mosley
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Deary, I. J.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Molecular Psychi ...
- By the university
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Stockholm University
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Umeå University
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Karolinska Institutet