Search: onr:"swepub:oai:DiVA.org:su-116630" >
Detection of Benz[j...
Detection of Benz[j]aceanthrylene in Urban Air and Evaluation of Its Genotoxic Potential
-
- Lim, Hwanmi (author)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
-
- Mattsson, Åse (author)
- Karolinska Institutet
-
Jarvis, Ian W. H. (author)
-
show more...
-
- Bergvall, Christoffer (author)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
-
- Bottai, Matteo (author)
- Karolinska Institutet
-
Morales, Daniel A. (author)
-
Kummrow, Fabio (author)
-
Umbuzeiro, Gisela A. (author)
-
- Stenius, Ulla (author)
- Karolinska Institutet
-
- Westerholm, Roger (author)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
-
- Dreij, Kristian (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
-
-
show more...
-
-
show less...
- ISSN 0013-936X
- 2015-02-09
- 2015
- English.
-
In: Environmental Science and Technology. - Stockholm : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 49:5, s. 3101-3109
- Related links:
-
http://openarchive.k...
-
show more...
-
http://hdl.handle.ne... (primary) (Object in context) (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://hdl.handle.ne...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Benz[j]aceanthrylene (B[j]A) is a cyclopenta-fused polycyclic aromatic hydrocarbon with strong mutagenic and carcinogenic effects. We have identified B[j]A in air particulate matter (PM) in samples collected in Stockholm, Sweden and in Limeira, Brazil using LC-GC/MS analysis. Determined concentrations ranged between 1.57 and 12.7 and 19.6-30.2 pg/m(3) in Stockholm and Limeira, respectively, which was 11-30 times less than benzo[a]pyrene (B[a]P) concentrations. Activation of the DNA damage response was evaluated after exposure to B[j]A in HepG2 cells in comparison to B[a]P. We found that significantly lower concentrations of B[j]A were needed for an effect on cell viability compared to B[a]P, and equimolar exposure resulted in significant more DNA damage with B[j]A. Additionally, levels of gamma H2AX, pChk1, p53, pp53, and p21 proteins were higher in response to B[j]A than B[a]P. On the basis of dose response induction of pChk1 and gamma H2AX, B[j]A potency was 12.5- and 33.3-fold higher than B[a]P, respectively. Although B[j]A levels in air were low, including B[j]A in the estimation of excess lifetime cancer risk increased the risk up to 2-fold depending on which potency factor for B[j]A was applied. Together, our results show that B[j]A could be an important contributor to the cancer risk of air PM.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Keyword
- Analytical Chemistry
- analytisk kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lim, Hwanmi
-
Mattsson, Åse
-
Jarvis, Ian W. H ...
-
Bergvall, Christ ...
-
Bottai, Matteo
-
Morales, Daniel ...
-
show more...
-
Kummrow, Fabio
-
Umbuzeiro, Gisel ...
-
Stenius, Ulla
-
Westerholm, Roge ...
-
Dreij, Kristian
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
-
and Analytical Chemi ...
- Articles in the publication
-
Environmental Sc ...
- By the university
-
Stockholm University
-
Karolinska Institutet